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Effects of methotrexate and other antifolates on the growth and dihydrofolate reductase activity of Leishmania promastigotes.

作者信息

Scott D A, Coombs G H, Sanderson B E

出版信息

Biochem Pharmacol. 1987 Jun 15;36(12):2043-5. doi: 10.1016/0006-2952(87)90508-9.

DOI:10.1016/0006-2952(87)90508-9
PMID:3593407
Abstract
摘要

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Effects of methotrexate and other antifolates on the growth and dihydrofolate reductase activity of Leishmania promastigotes.
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In vivo measurement of dihydrofolate reductase and its inhibition by antifolates.二氢叶酸还原酶的体内测量及其被抗叶酸剂的抑制作用
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PLoS One. 2012;7(1):e30746. doi: 10.1371/journal.pone.0030746. Epub 2012 Jan 26.
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Increased transport of pteridines compensates for mutations in the high affinity folate transporter and contributes to methotrexate resistance in the protozoan parasite Leishmania tarentolae.蝶啶转运增加可补偿高亲和力叶酸转运体的突变，并导致原生动物寄生虫热带利什曼原虫对甲氨蝶呤产生抗性。
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Antimicrob Agents Chemother. 1989 Nov;33(11):1860-3. doi: 10.1128/AAC.33.11.1860.