Zhao Hong-Zhe, Wang Feng-Xue, Han Xiao-Yu, Guo Hao, Liu Chun-Yu, Hou Li-Na, Wang Ya-Xin, Zheng Hui, Wang Lu, Wen Yong-Jun
Key Laboratory for Clinical Diagnosis and Treatment of Animal Diseases of Ministry of Agriculture, College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, China.
Front Microbiol. 2022 Jul 22;13:950402. doi: 10.3389/fmicb.2022.950402. eCollection 2022.
Since porcine reproductive and respiratory syndrome virus (PRRSV) was first described in China in 1996, several genetically distinct strains of PRRSV have emerged with varying pathogenicity and severity, thereby making the prevention and control of PRRS more difficult in China and worldwide. Between 2017 and 2021, the detection rate of NADC34-like strain in China increased. To date, NADC34-like strains have spread to 10 Chinese provinces and have thus developed different degrees of pathogenicity and mortality. In this review, we summarize the history of NADC34-like strains in China and clarify the prevalence, genomic characteristics, restriction fragment length polymorphisms, recombination, pathogenicity, and vaccine status of this strain in China. In so doing, this study aims to provide a basis for the further development of prevention and control measures targeting the NADC34-like strain.
自1996年猪繁殖与呼吸综合征病毒（PRRSV）首次在中国被发现以来，出现了几种基因上不同的PRRSV毒株，其致病性和严重程度各不相同，从而使中国乃至全球的PRRS防控工作更加困难。2017年至2021年间，中国NADC34样毒株的检出率有所上升。迄今为止，NADC34样毒株已传播至中国10个省份，并因此产生了不同程度的致病性和死亡率。在这篇综述中，我们总结了中国NADC34样毒株的历史，并阐明了该毒株在中国的流行情况、基因组特征、限制性片段长度多态性、重组情况、致病性及疫苗现状。通过这样做，本研究旨在为进一步制定针对NADC34样毒株的防控措施提供依据。
