Department of Reproductive Medicine, First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi, Xinjiang 832003, China.
Clinical Laboratory, First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi, Xinjiang 832003, China.
Contrast Media Mol Imaging. 2022 Jul 19;2022:1865189. doi: 10.1155/2022/1865189. eCollection 2022.
The expression of serum MMP-2 and von Willebrand factor (vWF) in patients with acute myeloid leukemia (AML) at different risks and their predictive value and prognostic impact were investigated. A total of 105 AML patients admitted to our hospital from February 2020 to February 2022 are divided into group A (32 cases), group B (46 cases), and group C (27 cases) according to risk stratification from low to high. The patients in the three groups are treated with induction chemotherapy according to the risk grade, and the expression of serum matrix metalloproteinase-2 (MMP-2) and vWF antigen in the three groups are detected before and after treatment. Pearson correlation is used to analyze the correlation between MMP-2 and vWF expression and prognosis of AML patients. ROC curve is used to analyze the predictive value of MMP-2 and vWF expression for risk grading of AML patients. MMP-2 and vWF are highly expressed in middle and high-risk patients, had high predictive value for the risk grade of AML patients, and are correlated with the prognosis of AML patients to a certain extent.
探讨了不同风险急性髓系白血病（AML）患者血清基质金属蛋白酶-2（MMP-2）和血管性血友病因子（vWF）的表达及其预测价值和预后影响。收集 2020 年 2 月至 2022 年 2 月我院收治的 105 例 AML 患者，根据风险分层由低到高分为 A 组（32 例）、B 组（46 例）和 C 组（27 例）。三组患者根据风险等级进行诱导化疗，检测三组患者治疗前后血清基质金属蛋白酶-2（MMP-2）和 vWF 抗原的表达。采用 Pearson 相关性分析 MMP-2 和 vWF 表达与 AML 患者预后的相关性。ROC 曲线分析 MMP-2 和 vWF 表达对 AML 患者风险分级的预测价值。中高危患者 MMP-2 和 vWF 表达水平较高，对 AML 患者的风险分级具有较高的预测价值，与 AML 患者的预后有一定的相关性。
