London W P
Alcohol. 1987 May-Jun;4(3):207-8. doi: 10.1016/0741-8329(87)90044-9.
This paper suggests that the strategy of studying individuals at high risk to develop alcoholism by comparing, for example, sons of alcoholic fathers with sons of nonalcoholic fathers might not control for handedness or for patterns of cerebral laterality. In our sample of alcoholic men, at least 50% of the men left-handed or having a left-handed first-degree relative had an alcoholic father, versus only 26% of the right-handed men not having a left-handed first-degree relative. If generalized to nonalcoholic individuals, these data suggest that a larger proportion of the sons of alcoholic fathers either would be left-handed or would have a left-handed first-degree relative, and might have an anomalous pattern of cerebral dominance. Furthermore, several findings associated with being at high risk for alcoholism have also been associated with left-handedness or with left-hemisphere dysfunction.
本文指出，通过比较例如酗酒父亲的儿子与非酗酒父亲的儿子来研究有酗酒风险个体的策略，可能无法控制利手或大脑偏侧性模式。在我们的酗酒男性样本中，至少50%的左利手男性或有左利手一级亲属的男性有酗酒的父亲，而在没有左利手一级亲属的右利手男性中这一比例仅为26%。如果将这些数据推广到非酗酒个体，表明酗酒父亲的儿子中更大比例要么是左利手，要么有左利手一级亲属，并且可能有异常的大脑优势模式。此外，一些与酗酒高风险相关的发现也与左利手或左半球功能障碍有关。
