Ethanol and current thresholds for brain self-stimulation in the lateral hypothalamus of the rat.

Two groups of animals were implanted with stimulating electrodes in the lateral hypothalamus for intracranial self-stimulation (ICSS). Following surgery these animals were trained in the auto-titration, brain self-stimulation procedure which measured both the rate of responding and the reinforcement threshold for electrical stimulation. When behavior was stable, one group was given saline or ethanol (0.1-1.7 g/kg) administered intraperitoneally (IP) either 15 or 60 min before testing. The other group was given saline or ethanol (1.0-4.5 g/kg) administered intragastrically (IG) 15 or 60 min before testing. With IP administration, there was a graded decrease in lever-pressing at 15 min but the effect was less obvious at 60 min. There were no changes in threshold except at the highest dose when behavior was disrupted. With IG administration, a reduction in the rate of responding occurred at 15 min only. No changes in thresholds were observed at any dose level or injection-test interval. Thus, administration of ethanol either by the IP or IG route did not affect the reinforcement thresholds for ICSS in the lateral hypothalamus, and these results contrasted with those of other drugs of abuse such as amphetamine or morphine.