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Small molecule inhibitor of Igf2bp1 represses Kras and a pro-oncogenic phenotype in cancer cells.小分子抑制剂 Igf2bp1 抑制 Kras 和肿瘤细胞中的致癌表型。
RNA Biol. 2022;19(1):26-43. doi: 10.1080/15476286.2021.2010983. Epub 2021 Dec 31.
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Inhibition of the mRNA-Binding Protein IGF2BP1 Suppresses Proliferation and Sensitizes Neuroblastoma Cells to Chemotherapeutic Agents.mRNA结合蛋白IGF2BP1的抑制可抑制神经母细胞瘤细胞增殖并使其对化疗药物敏感。
Front Oncol. 2021 Mar 16;11:608816. doi: 10.3389/fonc.2021.608816. eCollection 2021.
3
The oncofetal RNA-binding protein IGF2BP1 is a druggable, post-transcriptional super-enhancer of E2F-driven gene expression in cancer.癌胚 RNA 结合蛋白 IGF2BP1 是一种可药物治疗的、转录后 E2F 驱动的基因表达的超级增强子,在癌症中。
Nucleic Acids Res. 2020 Sep 4;48(15):8576-8590. doi: 10.1093/nar/gkaa653.
4
Extracellular vesicle-dependent effect of RNA-binding protein IGF2BP1 on melanoma metastasis.IGF2BP1 等 RNA 结合蛋白通过细胞外囊泡影响黑色素瘤转移。
Oncogene. 2019 May;38(21):4182-4196. doi: 10.1038/s41388-019-0797-3. Epub 2019 Apr 1.
5
p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors.p62/SQSTM1 通过拮抗一组选择性促转移因子的 mRNA 降解来促进黑色素瘤的进展。
Cancer Cell. 2019 Jan 14;35(1):46-63.e10. doi: 10.1016/j.ccell.2018.11.008. Epub 2018 Dec 20.
6
Protein kinase C-α is upregulated by IMP1 in melanoma and is linked to poor survival.IMP1 上调黑色素瘤中的蛋白激酶 C-α,与不良预后相关。
Melanoma Res. 2019 Oct;29(5):539-543. doi: 10.1097/CMR.0000000000000558.
7
Targeting insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in metastatic melanoma to increase efficacy of BRAF inhibitors.靶向转移性黑色素瘤中的胰岛素样生长因子2 mRNA结合蛋白1(IGF2BP1)以提高BRAF抑制剂的疗效。
Mol Carcinog. 2018 May;57(5):678-683. doi: 10.1002/mc.22786. Epub 2018 Feb 5.
8
Oncogenic Role of THOR, a Conserved Cancer/Testis Long Non-coding RNA.THOR的致癌作用,一种保守的癌/睾丸长链非编码RNA。
Cell. 2017 Dec 14;171(7):1559-1572.e20. doi: 10.1016/j.cell.2017.11.040.
9
A Novel IMP1 Inhibitor, BTYNB, Targets c-Myc and Inhibits Melanoma and Ovarian Cancer Cell Proliferation.新型IMP1抑制剂BTYNB靶向c-Myc并抑制黑色素瘤和卵巢癌细胞增殖。
Transl Oncol. 2017 Oct;10(5):818-827. doi: 10.1016/j.tranon.2017.07.008. Epub 2017 Aug 29.
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Potential Prognostic Molecular Signatures in a Preclinical Model of Melanoma.黑色素瘤临床前模型中的潜在预后分子特征
Anticancer Res. 2017 Jan;37(1):143-148. doi: 10.21873/anticanres.11299.

IGF2BP1, a New Target to Overcome Drug Resistance in Melanoma?

作者信息

Xi Yufeng, Wang Yujia

机构信息

Department of Neonatology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Department of Dermatology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.

出版信息

Front Pharmacol. 2022 Jul 22;13:947363. doi: 10.3389/fphar.2022.947363. eCollection 2022.

DOI:10.3389/fphar.2022.947363
PMID:35935853
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9354603/
Abstract
摘要