Zhang Wenwen, Cui Yifang, Zhang Jiayu
The School of Pharmacy, Binzhou Medical University, Yantai, China.
The School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China.
Front Pharmacol. 2022 Jul 22;13:948939. doi: 10.3389/fphar.2022.948939. eCollection 2022.
Hyperuricemia (HUA) is a common metabolic disease that is an independent risk factor for comorbidities such as hypertension, chronic kidney disease, and coronary artery disease. The prevalence of HUA has increased over the last several decades with improved living standards and increased lifespans. Metabolites are considered the most direct reflection of individual physiological and pathological conditions, and represent attractive candidates to provide deep insights into disease phenotypes. Metabolomics, a technique used to profile metabolites in biofluids and tissues, is a powerful tool for identification of novel biomarkers, and can be used to provide valuable insights into the etiopathogenesis of metabolic diseases and to evaluate the efficacy of drugs. In this study, multi metabolomics-based analysis of the blood, urine, and feces of rats with HUA showed that HUA significantly altered metabolite profiles. (AM) and benbromomalone significantly mitigated these changes in blood and feces, but not in urine. Some crucial metabolic pathways including lipid metabolism, lipid signaling, hormones synthesis, unsaturated fatty acid (UFAs) absorption, and tryptophan metabolism, were seriously disrupted in HUA rats. In addition, AM administration exerted better treatment effects on HUA than benbromomalone. Furthermore, additional supplementation with UFAs and tryptophan may also induce therapeutic effects against HUA.
高尿酸血症（HUA）是一种常见的代谢性疾病，是高血压、慢性肾病和冠状动脉疾病等合并症的独立危险因素。在过去几十年中，随着生活水平的提高和寿命的延长，HUA的患病率有所上升。代谢物被认为是个体生理和病理状况的最直接反映，是深入了解疾病表型的有吸引力的候选物。代谢组学是一种用于分析生物流体和组织中代谢物的技术，是鉴定新型生物标志物的强大工具，可用于深入了解代谢性疾病的病因发病机制并评估药物疗效。在本研究中，基于多代谢组学对HUA大鼠的血液、尿液和粪便进行分析，结果表明HUA显著改变了代谢物谱。氨基蝶呤（AM）和苯溴马隆显著减轻了血液和粪便中的这些变化，但对尿液中的变化没有影响。一些关键的代谢途径，包括脂质代谢、脂质信号传导、激素合成、不饱和脂肪酸（UFA）吸收和色氨酸代谢，在HUA大鼠中受到严重破坏。此外，AM给药对HUA的治疗效果优于苯溴马隆。此外，额外补充UFA和色氨酸也可能对HUA产生治疗作用。
