School of Medical Imaging, Xuzhou Medical University, Xuzhou 221000, China.
Department of Radiation Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221000, China.
Comput Math Methods Med. 2022 Jul 27;2022:9547166. doi: 10.1155/2022/9547166. eCollection 2022.
This study is aimed at analyzing the factors affecting the recurrence patterns and recurrence-free survival (RFS) of high-grade gliomas (HGG).
Eligible patients admitted to the Affiliated Hospital of Xuzhou Medical University were selected. Subsequently, the effects of some clinical data including age, gender, WHO pathological grades, tumor site, tumor size, clinical treatments, and peritumoral edema (PTE) area and molecular markers (Ki-67, MGMT, IDH-1, and p53) on HGG patients' recurrence patterns and RFS were analyzed.
A total number of 77 patients were enrolled into this study. After analyzing all the cases, it was determined that tumor size and tumor site had a significant influence on the recurrent patterns of HGG, and PTE was an independent predict factor of recurrence patterns. Specifically, when the PTE was mild (<1 cm), the recurrence pattern tended to be local; in contrast, HGG was more likely to progress to marginal recurrence and distant recurrence. Furthermore, age and PTE were significantly associated with RFS; the median RFS of the population with PTE < 1 cm (23.60 months) was obviously longer than the population with PTE ≥ 1 cm (5.00 months).
PTE is an independent predictor of recurrence patterns and RFS for HGG. Therefore, preoperative identification of PTE in HGG patients is crucially important, which is helpful to accurately estimate the recurrence pattern and RFS.
本研究旨在分析影响高级别胶质瘤（HGG）复发模式和无复发生存（RFS）的因素。
选取徐州医科大学附属医院收治的符合条件的患者。随后，分析了一些临床数据对 HGG 患者复发模式和 RFS 的影响，包括年龄、性别、世界卫生组织（WHO）病理分级、肿瘤部位、肿瘤大小、临床治疗以及瘤周水肿（PTE）面积和分子标志物（Ki-67、MGMT、IDH-1 和 p53）。
本研究共纳入 77 例患者。对所有病例进行分析后发现，肿瘤大小和肿瘤部位对 HGG 的复发模式有显著影响，PTE 是复发模式的独立预测因素。具体来说，当 PTE 轻度（<1cm）时，肿瘤复发模式倾向于局部；相反，HGG 更有可能进展为边缘性复发和远处复发。此外，年龄和 PTE 与 RFS 显著相关；PTE<1cm 人群的中位 RFS（23.60 个月）明显长于 PTE≥1cm 人群（5.00 个月）。
PTE 是 HGG 复发模式和 RFS 的独立预测因素。因此，术前识别 HGG 患者的 PTE 至关重要，有助于准确评估复发模式和 RFS。
