Alam Mohammad A
The Department of Chemistry and Physics, College of Sciences and Mathematics, Arkansas State University, Jonesboro, AR 72401, USA.
Curr Org Chem. 2022;26(4):343-347. doi: 10.2174/1385272826666220214110118. Epub 2022 Mar 24.
Substituted thiazoles are widely known as natural products, approved drugs, and a number of synthetic compounds as bioactive agents. Due to the worth of this heterocycle nucleus, a large number of synthetic methodologies have been reported over the years to synthesize its derivatives. In this perspective, recent advances in the synthesis of thiazole compounds by using domino/cascade and multicomponent approaches have been summarized.
取代噻唑作为天然产物、获批药物以及许多具有生物活性的合成化合物而广为人知。由于这种杂环核的价值,多年来已报道了大量用于合成其衍生物的合成方法。从这个角度出发,本文总结了利用多米诺/串联和多组分方法合成噻唑化合物的最新进展。