Department of Anesthesiology, First Affiliated Hospital with Nanjing Medical University, Nanjing 201129, Jiangsu, China.
Comput Intell Neurosci. 2022 Jul 19;2022:8527568. doi: 10.1155/2022/8527568. eCollection 2022.
In order to explore the effects of dexmedetomidine (DEX) on functional magnetic resonance imaging (fMRI) and emergence agitation of patients who underwent general anesthesia surgery with sevoflurane under comfortable nursing intervention, 66 patients who received upper abdominal surgery were selected as research objects. According to nursing and anesthesia methods, the patients were randomly divided into control group (routine nursing and anesthesia), group A (routine nursing and DEX-assisted anesthesia), and group B (comfortable nursing and DEX-assisted anesthesia). The differences in the brain fMRI characteristics, hemodynamic indexes, anesthesia recovery indexes, and nursing satisfaction in the perioperative period were evaluated. The results showed that the regional homogeneity values were different in different brain regions, but there was no difference in the value of functional connectivity( > 0.05). Compared with the control group, heart rate, mean arterial pressure, awakening time, extubation time, the Riker sedation-agitation scale (SAS) score, and anesthetic dosage were signally decreased in group A and group B, while the Ramsay scores, the postanesthesia care unit (PACU) stay, and anesthesia maintenance time in the two groups was obviously increased( < 0.05). Compared with group A, the extubation time, the SAS score, PACU stay, and hospital stay were all remarkably reduced in group B, while the nursing satisfaction score was greatly increased( < 0.05). To sum up, DEX was helpful to safely and effectively reduce the occurrence of emergence agitation in patients under general anesthesia surgery with sevoflurane. Besides, comfortable nursing intervention could further reduce the incidence of emergence agitation in patients with general anesthesia, shorten the length of hospital stay, and improve nursing satisfaction.
为了探索右美托咪定（DEX）对舒适护理干预下接受七氟醚全身麻醉手术患者的功能磁共振成像（fMRI）和苏醒躁动的影响，选择 66 例接受上腹部手术的患者作为研究对象。根据护理和麻醉方法，将患者随机分为对照组（常规护理和麻醉）、A 组（常规护理和 DEX 辅助麻醉）和 B 组（舒适护理和 DEX 辅助麻醉）。评估围手术期脑 fMRI 特征、血流动力学指标、麻醉恢复指标和护理满意度的差异。结果显示，不同脑区的局部一致性值不同，但功能连接的 值无差异（>0.05）。与对照组相比，A 组和 B 组的心率、平均动脉压、苏醒时间、拔管时间、Riker 镇静躁动量表（SAS）评分和麻醉剂量均显著降低，而 Ramsay 评分、麻醉后护理单元（PACU）停留时间和麻醉维持时间均明显增加（<0.05）。与 A 组相比，B 组的拔管时间、SAS 评分、PACU 停留时间和住院时间均显著降低，护理满意度评分显著升高（<0.05）。总之，DEX 有助于安全有效地降低七氟醚全身麻醉手术患者苏醒躁动的发生率。此外，舒适护理干预可进一步降低全身麻醉患者苏醒躁动的发生率，缩短住院时间，提高护理满意度。
