Blood Transfusion Department, Beidahuang Group General Hospital, Harbin, 150088 Heilongjiang, China.
Department of Dermatology, The First Hospital of Heilongjiang Harbin, Harbin, 150010 Heilongjiang, China.
Biomed Res Int. 2022 Jul 29;2022:7117627. doi: 10.1155/2022/7117627. eCollection 2022.
To explore the clinical efficacy of microneedle injection combined with blood transfusion in the treatment of severe anemia complicated with vitiligo based on regenerative medical technology and provide the theoretical basis for the adoption of microneedle technology, 60 patients with severe anemia complicated with vitiligo were selected as research objects. With 15 patients in each group, they were randomly assigned to the control group (calcipotriol ointment external application), observation group A (external application of moist exposed burn ointment (MEBO), observation group B (external application of MEBO combined with blood transfusion), and observation group C (microneedle injection of MEBO combined with blood transfusion). Blood indexes and plaque recovery of patients in different periods were detected. The total protein (TP) content in group C (62.3 ± 3.3 g/L and 64.3 ± 2.88 g/L) was remarkably higher than that in the control group (51.3 ± 3.17 g/L and 52.4 ± 3.17 g/L) and group A (52.6 ± 2.91 g/L and 51.8 ± 2.98 g/L)) at the 5th and 7th weeks after the treatment ( < 0.05). The albumin (ALB) content in group C (42.9 ± 3.28 g/L and 45.3 ± 3.1 g/L) was signally higher than that in the control group (41.8 ± 3.44 g/L and 41.9 ± 3.23 g/L) and group A (41.3 ± 2.91 g/L and 42.1 ± 3.02 g/L) at the 5th and 7th weeks after the treatment, and the content was markedly higher than that in group B at 5th week ( < 0.05). The wound healing rates of group C at the 3rd, 5th, and 7th weeks after the treatment (38.44%, 56.6%, and 90.23%) were greatly higher than those of the control group, group A, and group B ( < 0.05). Besides, the wound healing rate of group B was higher than that of the control group and group A (40.3% and 75.8%) at the 5th and 7th weeks after the treatment ( < 0.05). To sum up, based on regenerative medical technology, microneedle injection (microneedling is a derma roller process that pricks the skin with minuscule needles. The goal of the treatment is to develop new collagen and skin tissue, resulting in skin that is smoother, firmer, and more toned) combined with blood transfusion had a good therapeutic effect on patients with severe anemia complicated with vitiligo, which could manifestly improve the blood indexes and skin plaques of patients, with a good clinical adoption effect.
为探索基于再生医学技术的微针注射联合输血治疗重度贫血合并白癜风的临床疗效，为采用微针技术提供理论依据，选取 60 例重度贫血合并白癜风患者作为研究对象，每组 15 例，随机分为对照组（卡泊三醇软膏外用）、观察组 A（湿润烧伤膏外用）、观察组 B（湿润烧伤膏联合输血）、观察组 C（微针注射联合输血）。检测不同时期患者的血液指标和斑块恢复情况。治疗后第 5、7 周时，C 组（62.3±3.3g/L、64.3±2.88g/L）总蛋白（TP）含量显著高于对照组（51.3±3.17g/L、52.4±3.17g/L）和观察组 A（52.6±2.91g/L、51.8±2.98g/L）（<0.05）。治疗后第 5、7 周时，C 组（42.9±3.28g/L、45.3±3.1g/L）白蛋白（ALB）含量明显高于对照组（41.8±3.44g/L、41.9±3.23g/L）和观察组 A（41.3±2.91g/L、42.1±3.02g/L），且第 5 周时 C 组明显高于观察组 B（<0.05）。治疗后第 3、5、7 周时，C 组创面愈合率（38.44%、56.6%、90.23%）明显高于对照组、观察组 A 和观察组 B（<0.05）。此外，治疗后第 5、7 周时，观察组 B 的创面愈合率高于对照组和观察组 A（40.3%和 75.8%）（<0.05）。综上所述，基于再生医学技术，微针注射（微针是一种使用微小针头刺穿皮肤的真皮滚轮过程。治疗的目的是产生新的胶原蛋白和皮肤组织，从而使皮肤更加光滑、紧致和有弹性）联合输血治疗重度贫血合并白癜风患者具有良好的治疗效果，可明显改善患者的血液指标和皮肤斑块，具有良好的临床应用效果。
