Huang Hongjian, Xu Renfeng, Ni Peng, Zhang Zhenghong, Sun Caixia, He Huaying, Wang Xinyue, Zhang Lidan, Liang Ziyi, Liu Haiqing
Fujian Key Laboratory of Polymer Materials, College of Chemistry and Materials Science, Fujian Normal University, Fujian, 350007, China.
College of Life Science, Fujian Normal University, Fujian, 350007, China.
Mater Today Bio. 2022 Jul 19;16:100369. doi: 10.1016/j.mtbio.2022.100369. eCollection 2022 Dec.
Tissue adhesive with on-demand detachment feature is critically important since it can minimize hurt to patient when it is stripped away. Herein, a water-driven noninvasively detachable wet tissue adhesive hydrogel (w-TAgel) was produced by UV-initiated radical copolymerization of N-isopropylacrylamide (NIPAM), acrylamide (AAm), gelatin methacrylate (GelMA), and urushiol. As a w-TAgel, its robust and tough mechanical property makes it suitable for dynamic wound tissue. The polyurushiol segments of it are crucial to the formation of tough adhesion interface with various wet tissues, while polyNIPAM units play an indispensable role in on-demand detachment via thermo-responsive swelling behavior because the hydrophobic aggregation among isopropyl groups is destroyed upon water treatment with temperature of 25 °C or less. Additionally, it exhibits multiple merits including good hemocompatibility, cytocompatibility as well as pro-coagulant activity and hemostasis. Therefore, our w-TAgel with strong adhesion and facile detachment is an advanced prospective dressing for wound closure and rapid hemostasis. The wet tissue adhesion and water-driven detachable mechanism may shed new light on the development of on-demand noninvasively detachable wet tissue adhesives.
具有按需分离功能的组织粘合剂至关重要，因为在剥离时它可以将对患者的伤害降至最低。在此，通过N-异丙基丙烯酰胺（NIPAM）、丙烯酰胺（AAm）、甲基丙烯酸明胶（GelMA）和漆酚的紫外光引发自由基共聚制备了一种水驱动的非侵入性可分离湿组织粘合剂水凝胶（w-TAgel）。作为一种w-TAgel，其强大而坚韧的机械性能使其适用于动态伤口组织。其聚漆酚链段对于与各种湿组织形成坚韧的粘附界面至关重要，而聚NIPAM单元通过热响应溶胀行为在按需分离中发挥不可或缺的作用，因为在25℃或更低温度的水处理下，异丙基之间的疏水聚集被破坏。此外，它还具有多种优点，包括良好的血液相容性、细胞相容性以及促凝血活性和止血作用。因此，我们的具有强粘附力和易于分离的w-TAgel是一种用于伤口闭合和快速止血的先进的前瞻性敷料。湿组织粘附和水驱动分离机制可能为按需非侵入性可分离湿组织粘合剂的开发提供新的思路。
