Sanfilippo Michelle J, Layshock Mary E, Keniston Leslie
Department of Physical Therapy, University of Maryland Eastern Shore: 1 College Backbone Road, Princess Anne, MD 21853, USA.
J Phys Ther Sci. 2022 Aug;34(8):532-539. doi: 10.1589/jpts.34.532. Epub 2022 Aug 3.
[Purpose] The usefulness and limitations of outcome measures changes throughout functional decline of patients with Amyotrophic Lateral Sclerosis (ALS). This study aims to describe associations between outcome measures in patients with ALS over time. [Participants and Methods] Participant data was collected at a multidisciplinary ALS clinic during regular clinic visits, including gait velocity, Timed Up and Go, the ALS Functional Rating Scale-Revised, and it's Gross Motor Subscale. [Results] All gait velocity measures were <1.2 m/sec; average Timed Up and Go was >13.5 sec. There was strong internal consistency between ALS Functional Rating Scale-Revised and its functional mobility components and a strong, significant correlation between the Timed Up and Go and the Gross Motor Subscale. [Conclusion] Patients with ALS are not community ambulators and demonstrate risk for falls. We found concurrent validity between objective and self-reported measures. The strong association between the Gross Motor Subscale and the Timed Up and Go may allow PTs to utilize the self-reported Gross Motor Subscale to predict fall risk. Clinically, when the Timed Up and Go and gait velocity are no longer appropriate due to disease progression, the Gross Motor Subscale can provide insight into functional decline.
[目的] 随着肌萎缩侧索硬化症（ALS）患者功能衰退，结局指标的效用和局限性也会发生变化。本研究旨在描述ALS患者结局指标随时间的关联。[参与者与方法] 在多学科ALS诊所定期门诊期间收集参与者数据，包括步速、计时起立行走测试、修订版ALS功能评定量表及其粗大运动分量表。[结果] 所有步速测量值均<1.2米/秒；平均计时起立行走测试时间>13.5秒。修订版ALS功能评定量表与其功能移动性分量表之间具有很强的内部一致性，计时起立行走测试与粗大运动分量表之间存在强且显著的相关性。[结论] ALS患者并非社区行走者，且有跌倒风险。我们发现客观测量与自我报告测量之间具有同时效度。粗大运动分量表与计时起立行走测试之间的强关联可能使物理治疗师能够利用自我报告的粗大运动分量表来预测跌倒风险。临床上，当由于疾病进展计时起立行走测试和步速不再适当时，粗大运动分量表可提供功能衰退的相关信息。
