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Elecsys核衣壳检测法对检测既往新冠病毒感染的敏感性。

Sensitivity of the Elecsys Nucleocapsid Assay for the Detection of Preceding SARS-CoV-2 Infections.

作者信息

Grunau Brian, Tom Janessa, Asamoah-Boaheng Michael, O'Brien Sheila F, Drews Steven J, Sediqi Sadaf, Lavoie Pascal M, Barakauskas Vilte, Goldfarb David M

机构信息

Centre for Health Evaluation & Outcome Sciences, St. Paul's Hospital, Vancouver, British Columbia, Canada.

British Columbia Emergency Health Services, Vancouver, British Columbia, Canada.

出版信息

Open Forum Infect Dis. 2022 Jul 26;9(8):ofac349. doi: 10.1093/ofid/ofac349. eCollection 2022 Aug.

DOI:10.1093/ofid/ofac349
PMID:35937649
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9350617/
Abstract

Nucleocapsid serological assay sensitivity to identify severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections among vaccinees and for Omicron cases is unclear. In this prospective study, the Elecsys nucleocapsid assay was 89% sensitive in identifying SARS-CoV-2 infections 14-607 days pre-blood collection. Sensitivity was similar when comparing by vaccination status, and in Omicron (vs pre-Omicron) cases.

摘要

核衣壳血清学检测在识别疫苗接种者中的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染以及奥密克戎病例方面的敏感性尚不清楚。在这项前瞻性研究中，罗氏电化学发光免疫分析法（Elecsys）核衣壳检测在识别采血前14 - 607天的SARS-CoV-2感染时敏感性为89%。按疫苗接种状态以及在奥密克戎（与奥密克戎出现之前相比）病例中进行比较时，敏感性相似。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5f9/9350617/1f418b93a5ae/ofac349f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5f9/9350617/1f418b93a5ae/ofac349f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5f9/9350617/1f418b93a5ae/ofac349f1.jpg

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A Prospective Observational Cohort Comparison of SARS-CoV-2 Seroprevalence Between Paramedics and Matched Blood Donors in Canada During the COVID-19 Pandemic.在 COVID-19 大流行期间，加拿大对护理人员和匹配献血者的 SARS-CoV-2 血清阳性率进行前瞻性观察性队列比较。
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