Triccas Lisa Tedesco, Camilleri Kenneth P, Tracey Camilleri, Mansoureh Fahimi Hnazaee, Benjamin Wittevrongel, Francesca Muscat, Leonardo Boccuni, Dante Mantini, Geert Verheyden
Department of Rehabilitation Sciences, KU Leuven, Leuven, Belgium.
Department of Systems and Control Engineering, University of Malta, Msida, Malta.
Front Hum Neurosci. 2022 Jul 21;16:881291. doi: 10.3389/fnhum.2022.881291. eCollection 2022.
In order for electroencephalography (EEG) with sensory stimuli measures to be used in research and neurological clinical practice, demonstration of reliability is needed. However, this is rarely examined. Here we studied the test-retest reliability of the EEG latency and amplitude of evoked potentials and spectra as well as identifying the sources during pin-prick stimulation. We recorded EEG in 23 healthy older adults who underwent a protocol of pin-prick stimulation on the dominant and non-dominant hand. EEG was recorded in a second session with rest intervals of 1 week. For EEG electrodes Fz, Cz, and Pz peak amplitude, latency and frequency spectra for pin-prick evoked potentials was determined and test-retest reliability was assessed. Substantial reliability ICC scores (0.76-0.79) were identified for evoked potential negative-positive amplitude from the left hand at C4 channel and positive peak latency when stimulating the right hand at Cz channel. Frequency spectra showed consistent increase of low-frequency band activity (< 5 Hz) and also in theta and alpha bands in first 0.25 s. Almost perfect reliability scores were found for activity at both low-frequency and theta bands (ICC scores: 0.81-0.98). Sources were identified in the primary somatosensory and motor cortices in relation to the positive peak using s-LORETA analysis. Measuring the frequency response from the pin-prick evoked potentials may allow the reliable assessment of central somatosensory impairment in the clinical setting.
为了使带有感觉刺激测量的脑电图（EEG）能够用于研究和神经临床实践，需要证明其可靠性。然而，这很少被检验。在此，我们研究了EEG潜伏期、诱发电位和频谱的重测可靠性，并在针刺刺激过程中识别其来源。我们记录了23名健康老年人的EEG，他们在优势手和非优势手接受了针刺刺激方案。在间隔1周的第二次记录中再次记录EEG。对于EEG电极Fz、Cz和Pz，确定针刺诱发电位的峰值幅度、潜伏期和频谱，并评估重测可靠性。在C4通道从左手诱发出的电位负-正幅度以及在Cz通道刺激右手时的正峰值潜伏期的组内相关系数（ICC）得分具有较高的可靠性（0.76 - 0.79）。频谱显示在最初的0.25秒内低频带活动（< 5 Hz）以及θ和α波段持续增加。在低频和θ波段的活动发现了几乎完美的可靠性得分（ICC得分：0.81 - 0.98）。使用s - LORETA分析确定了与正峰值相关的初级体感皮层和运动皮层中的来源。测量针刺诱发电位的频率响应可能有助于在临床环境中可靠地评估中枢体感障碍。
