Ekker M, Sourkes T L
Biol Neonate. 1987;51(5):260-7. doi: 10.1159/000242662.
The concentrations of polyamines and the activities of ornithine decarboxylase (ODC) and of S-adenosylmethionine decarboxylase (SAM-DC) were measured in the adrenal glands of rats during development. Adrenal spermine content increases gradually during the first month of life whereas spermidine and putrescine decrease. A low spermidine/spermine ratio is obtained. The developmental pattern of adrenal SAM-DC resembles that of spermine content. The activity of adrenal ornithine decarboxylase increases after birth and attains a peak at 17 days of age. It declines sharply thereafter. Induction of adrenal ODC following the stress of immobilization is already observed in the rat at 4 days of age but the induction caused by maternal deprivation or cold exposure is obtained only at 17 days. The results suggest that the developmental pattern of ODC activity is independent of its responsivity to various stressors.
在大鼠发育过程中，测定了其肾上腺中多胺的浓度以及鸟氨酸脱羧酶（ODC）和S-腺苷甲硫氨酸脱羧酶（SAM-DC）的活性。在出生后的第一个月，肾上腺精胺含量逐渐增加，而亚精胺和腐胺含量则下降。由此得到较低的亚精胺/精胺比值。肾上腺SAM-DC的发育模式与精胺含量的模式相似。肾上腺鸟氨酸脱羧酶的活性在出生后增加，并在17日龄时达到峰值。此后急剧下降。在4日龄的大鼠中已经观察到固定应激后肾上腺ODC的诱导，但只有在17日龄时才出现由母体剥夺或冷暴露引起的诱导。结果表明，ODC活性的发育模式与其对各种应激源的反应性无关。
