College of Material Science and Engineering, Guilin University of Technology, Guilin, China.
Collaborative Innovation Center for Water Pollution Control and Water Safety in Karst Area, Guilin University of Technology, Guilin, China.
J Biomater Sci Polym Ed. 2023 Jan;34(1):89-107. doi: 10.1080/09205063.2022.2111651. Epub 2022 Aug 16.
As a substitute for feed antibiotics, potassium diformate (KDF) can effectively inhibit bacterial overgrowth in the gastrointestinal tract. To avoid the sudden release of KDF in the stomach, this article proposes a new controlled drug delivery system for controlled drug release. In this system, P-type zeolite molecular sieve (Zeolite P) and drug KDF are combined and embedded into the hydrogel microspheres of sodium alginate (ALG) and sodium carboxymethyl cellulose (CMC). In addition, ALG/CMC/Zeolite P composite hydrogel microspheres were prepared with Ca as the crosslinking agent. The structure, composition, morphology, and thermal stability of the hydrogel microspheres were systematically characterized. The effect of the composition ratio of ALG and CMC on the swelling properties of the hydrogel microspheres was also investigated. The results revealed that ALG and CMC form a hydrogen bond and chelate with Ca to form a double crosslinked network structure. Thus, Zeolite P can be effectively encapsulated in the hydrogel microspheres to form a dense three-dimensional network structure. Particularly, Zeolite P helps in improving the thermal stability of microspheres, balance the swelling properties, and control the release of KDF. The drug release results and release kinetics reveal that the ALG/CMC/Zeolite P composite hydrogel has higher drug release in an environment with pH 7.4. The release kinetics follow the Ritger-Peppas model and the first-order kinetic model, which indicates that the composite hydrogel has good specific pH sensitivity. antibacterial experiments revealed that the composite hydrogel microspheres have broad-spectrum antibacterial activity, and certain inhibitory effects on , , and .
作为饲料抗生素的替代品，双甲脒（KDF）可以有效抑制胃肠道细菌过度生长。为避免 KDF 在胃中突然释放，本文提出了一种新的控释给药系统，以实现药物的控释。在该系统中，将 P 型沸石分子筛（Zeolite P）与药物 KDF 结合并嵌入到海藻酸钠（ALG）和羧甲基纤维素钠（CMC）的水凝胶微球中。此外，还使用 Ca 作为交联剂制备了 ALG/CMC/Zeolite P 复合水凝胶微球。系统地表征了水凝胶微球的结构、组成、形貌和热稳定性。还研究了 ALG 和 CMC 的组成比对水凝胶微球溶胀性能的影响。结果表明，ALG 和 CMC 形成氢键，并与 Ca 螯合形成双交联网络结构。因此，Zeolite P 可以有效地包埋在水凝胶微球中，形成致密的三维网络结构。特别是，Zeolite P 有助于提高微球的热稳定性，平衡溶胀性能，并控制 KDF 的释放。药物释放结果和释放动力学表明，ALG/CMC/Zeolite P 复合水凝胶在 pH 值为 7.4 的环境中具有更高的药物释放率。释放动力学符合 Ritger-Peppas 模型和一级动力学模型，表明复合水凝胶具有良好的 pH 值特异性。抗菌实验表明，复合水凝胶微球具有广谱抗菌活性，对 、 、 和 有一定的抑制作用。
