Clinic for Poultry and Fish Medicine, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine, Vienna, Austria.
Avian Pathol. 2022 Dec;51(6):561-573. doi: 10.1080/03079457.2022.2108373. Epub 2022 Oct 12.
() Infantis is the most common serovar in broilers and broiler meat in the European Union. In the field, fast-growing broilers are reported to be more affected than slow-growing and layer birds. The present study investigated the infection dynamics and immunological response of four chicken lines in the course of a . Infantis infection. Two commercial chicken lines, Ross 308 and Hubbard ISA-JA-757, and two experimental chicken lines, specific pathogen free (SPF) layers and broilers, were infected at 2 days of age. Investigations focused on faecal shedding, bacterial colonization, humoral and cellular immune response. Ross and SPF broilers proved mainly as high shedders followed by Hubbard. SPF layers showed the least shedding. This is in agreement with the caecal colonization; SPF layers harboured significantly less bacteria. Systemic spread of . Infantis to liver and spleen was highest in Ross broilers compared to the other lines. Spread of infection to in-contact birds, was noticed 5 days post infection in every line. Antibody response occurred in every chicken line from 21 days of age onwards. In contrast to the other chicken lines, significant differences in T cell subsets and monocytes/macrophages were found between infected and negative Hubbard birds at 7 days of age. Uninfected SPF birds had significantly higher immune cell counts than uninfected commercial birds, a fact important for future experimental settings. The results illustrate that the infection dynamics of . Infantis is influenced by the chicken line resulting in a higher risk of transmission to humans from fast-growing broilers. Infection dynamics of Infantis differs between chicken lines.Layers showed less faecal shedding and caecal colonization compared to broilers.Fast-growing broilers proved more susceptible than slow-growing broilers.
鸡传染性鼻炎血清型 C 是欧盟范围内肉鸡和鸡肉中最常见的血清型。在实际生产中，快速生长的肉鸡比生长缓慢的肉鸡和蛋鸡更容易受到感染。本研究旨在调查鸡传染性鼻炎血清型 C 感染过程中四个鸡品系的感染动态和免疫反应。试验选择了两个商业肉鸡品系（罗斯 308 和哈伯德 ISA-JA-757）和两个实验性鸡品系（SPF 蛋鸡和肉鸡），于 2 日龄时感染鸡传染性鼻炎血清型 C。本研究重点关注粪便脱落、细菌定植、体液和细胞免疫反应。结果表明，罗斯和 SPF 肉鸡主要表现为高脱落，其次是哈伯德肉鸡。SPF 蛋鸡的脱落最少。这与盲肠定植情况一致；SPF 蛋鸡定植的细菌数量明显较少。与其他鸡品系相比，罗斯肉鸡的肝脏和脾脏中鸡传染性鼻炎血清型 C 的系统传播最高。在感染后 5 天，所有鸡品系均发现感染向接触鸡的传播。从 21 日龄起，所有鸡品系均出现抗体反应。与其他鸡品系相比，7 日龄时感染和未感染的哈伯德鸡之间的 T 细胞亚群和单核细胞/巨噬细胞存在显著差异。未感染的 SPF 鸡的免疫细胞计数明显高于未感染的商业鸡，这对于未来的实验设置非常重要。结果表明，鸡传染性鼻炎血清型 C 的感染动态受鸡品系的影响，这导致快速生长的肉鸡向人类传播的风险更高。鸡传染性鼻炎血清型 C 的感染动态在鸡品系之间存在差异。与肉鸡相比，蛋鸡的粪便脱落和盲肠定植较少。快速生长的肉鸡比生长缓慢的肉鸡更容易感染。
