Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Hokkaido, Japan.
Department of Biostatistics, Graduate School of Medicine, Hokkaido University, Hokkaido, Japan.
J Surg Oncol. 2022 Dec;126(7):1299-1305. doi: 10.1002/jso.27049. Epub 2022 Aug 8.
Fibrosarcomas predominantly arise in soft tissues, but can also develop in bone. Because of their rarity, whether bone development has an impact on clinical features has not been addressed.
We included fibrosarcoma patients diagnosed between 1983 and 2016 in the Surveillance, Epidemiology, and End Results database. Differences in clinical features between fibrosarcoma of bone (FS-B) and fibrosarcoma of soft tissue (FS-ST) were investigated.
After excluding patients without information regarding cause of death, site of origin, distant tumor or survival, 1443 patients were included. Of those, 98 patients had FS-B. Patients with FS-B were younger, more frequently male, with fibrosarcomas that more often developed in an extremity and were histologically high-grade. In contrast, no difference in potential to metastasize was observed. Survival was almost equal between FS-B and FS-ST (FS-B/FS-ST: cancer-specific survival, hazard ratio [HR]: 1.2, 95% confidence interval [CI]: 0.8-1.7; overall survival, HR: 1.3, 95% CI: 0.9-1.7).
Our results clearly indicated that patient backgrounds differed, such as younger age and greater tendencies to affect males, develop in an extremity and show high-grade tumor in patients with FS-B. In contrast, no differences were observed in distant metastatic potential or survival.
纤维肉瘤主要发生于软组织，但也可发生于骨骼。由于其罕见性，骨发育是否会影响临床特征尚未得到阐明。
我们纳入了 1983 年至 2016 年间监测、流行病学和最终结果数据库中的纤维肉瘤患者。研究了骨纤维肉瘤（FS-B）和软组织纤维肉瘤（FS-ST）之间的临床特征差异。
排除了无死亡原因、起源部位、远处肿瘤或生存信息的患者后，共纳入 1443 例患者。其中，98 例患者患有 FS-B。FS-B 患者更年轻，男性居多，纤维肉瘤更常发生于四肢，组织学分级更高。然而，转移潜能无差异。FS-B 和 FS-ST 的生存几乎相同（FS-B/FS-ST：癌症特异性生存，风险比 [HR]：1.2，95%置信区间 [CI]：0.8-1.7；总生存，HR：1.3，95%CI：0.9-1.7）。
我们的研究结果明确表明，FS-B 患者的背景不同，例如年龄较小，更易累及男性，发生于四肢且为高级别肿瘤。相比之下，在远处转移潜能或生存方面无差异。
