[对化学过敏原迟发型超敏反应稳定形式的模型]
[Model of a stable form of delayed hypersensitivity to chemical allergens].
作者信息
Chernousov A D, Medunitsyn N V
出版信息
Biull Eksp Biol Med. 1987 Jun;103(6):722-4.
The injection to mice of a water-soluble form of a chemical allergen (2, 4, 6-trinitrophenylsulfonic acid) in Freund Complete Adjuvant resulted in the development of extremely intensive and persistent (more than 14 weeks) sensibilization which was determined by skin tests. Depending on the challenge, the persistence of skin reactions varied from 48 to 244 hours, but an early component was detected 6 hours after the injection. When this sensibilization method is applied, the effectors of delayed type hypersensitivity are formed in the regional lymph nodes.
在弗氏完全佐剂中向小鼠注射化学变应原（2,4,6-三硝基苯磺酸）的水溶性形式，会导致产生极其强烈且持久（超过14周）的致敏反应，这通过皮肤试验得以确定。根据激发情况，皮肤反应的持续时间从48小时到244小时不等，但在注射后6小时可检测到早期成分。当应用这种致敏方法时，迟发型超敏反应的效应细胞在局部淋巴结中形成。
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