Department of Otolaryngology-Head and Neck Surgery, Sapporo Medical University, Sapporo, Japan.
Department of Rheumatology and Clinical Immunology, Sapporo Medical University, Sapporo, Japan.
Acta Otolaryngol. 2022 Jul-Aug;142(7-8):616-619. doi: 10.1080/00016489.2022.2104368. Epub 2022 Aug 8.
Tubarial glands (TGs) are a collection of unidentified salivary glands overlying the torus tubarius in the nasopharyngeal wall. Immunoglobulin G4-related disease (IgG4-RD) is a chronic fibroinflammatory state that often has multiple organ involvement. Involvement of the head and neck, especially the salivary glands, is common in IgG4-RD.
AIMS/OBJECTIVES: This study aimed to elucidate the clinical significance of TGs in IgG4-RD.
We investigated the local findings of TGs in ten patients with IgG4-RD.
Nasopharyngeal endoscopic examination revealed oedematous swelling of the nasopharyngeal wall surrounding the TGs, which improved after steroid treatment. Moreover, sonotubometry showed a stenotic pattern in three out of seven patients with IgG4-RD.
TGs may be involved in IgG4-RD. The swollen TGs may be responsible for obstructive Eustachian tube dysfunction. Further studies are required to clarify the clinical significance and physiological roles of TGs in IgG4-RD.
管周腺（TGs）是一种位于咽鼓管圆枕上方鼻咽壁的未明唾液腺集合。免疫球蛋白 G4 相关疾病（IgG4-RD）是一种慢性纤维炎症状态，常累及多个器官。头颈部受累，特别是唾液腺，在 IgG4-RD 中很常见。
目的/目标：本研究旨在阐明 TGs 在 IgG4-RD 中的临床意义。
我们研究了 10 例 IgG4-RD 患者的 TGs 局部表现。
鼻咽喉内镜检查显示 TGs 周围的鼻咽壁肿胀，经类固醇治疗后改善。此外，7 例 IgG4-RD 患者中有 3 例出现声导抗测试狭窄模式。
TGs 可能与 IgG4-RD 有关。肿胀的 TGs 可能导致咽鼓管功能障碍。需要进一步研究来阐明 TGs 在 IgG4-RD 中的临床意义和生理作用。
