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成人肋骨朗格汉斯细胞组织细胞增多症:一例报告并文献复习

Langerhans cell histiocytosis of the rib in an adult: A case report and review of the literature.

作者信息

Zhao Shengliang, Luo Chao, Tang Bo, Chen Liang, Xiang Mingzhang, Dai Jigang, Li Hua

机构信息

Department of Thoracic Surgery, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing 400037, China.

Department of Thoracic Surgery, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing 400037, China.

出版信息

Int J Surg Case Rep. 2022 Aug;97:107432. doi: 10.1016/j.ijscr.2022.107432. Epub 2022 Jul 21.

Abstract

INTRODUCTION AND IMPORTANCE

Langerhans cell histiocytosis (LCH) is a rare neoplastic hyperplasia with an unknown etiology. It is clinically rare for patients with solitary rib lesion and pathological fracture. In this article, we report a case of LCH in solitary involvement of rib and provide a review of the available literature.

CASE PRESENTATION

A 24-year-old female patient complained of right chest and back pain for 10 days. CT showed a fracture in the right 6th rib. Findings on X-ray, and CT were suggestive of homogeneous osteolytic lesion of the right 6th rib. The rib tumor was then resected and the surrounding muscles and soft tissues were accordingly resected.

CLINICAL DISCUSSION

The patient was diagnosed with pathological rib fracture, and the patient was pathologically diagnosed with LCH. After surgery, no local recurrence or distant metastasis was reported during the one-year follow-up.

CONCLUSIONS

Most of the solitary tumorous lesions in rib in adults call for various differential diagnoses. Although single-site, single-system LCH of the rib is one of the rarest causes of bone tumor in adults, it can be treated successfully with surgical intervention. LCH should be considered in the diagnosis of an adult patient with a rib mass.

摘要

引言与重要性

朗格汉斯细胞组织细胞增多症(LCH)是一种病因不明的罕见肿瘤性增生。孤立性肋骨病变并伴有病理性骨折的患者在临床上较为罕见。在本文中,我们报告一例孤立性肋骨受累的LCH病例,并对现有文献进行综述。

病例介绍

一名24岁女性患者主诉右胸和背部疼痛10天。CT显示右侧第6肋骨骨折。X线和CT检查结果提示右侧第6肋骨存在均匀性骨质溶解病变。随后切除肋骨肿瘤,并相应切除周围肌肉和软组织。

临床讨论

患者被诊断为病理性肋骨骨折,病理诊断为LCH。术后一年随访期间未报告局部复发或远处转移。

结论

成人肋骨的大多数孤立性肿瘤病变需要进行多种鉴别诊断。尽管肋骨单部位、单系统LCH是成人骨肿瘤最罕见的病因之一,但通过手术干预可成功治疗。在诊断成年肋骨肿物患者时应考虑LCH。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85d9/9403175/232736a36624/gr1ab.jpg

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