镧系放射性核素在钐-153-乙二胺四甲叉膦酸（Sm-EDTMP）放射性药物废物中的研究。

Europium radionuclides in samarium-153-Ethylene Diamine Tetramethylene phosphonic acid (Sm-EDTMP) radiopharmaceutical waste.

机构信息

Health Physics Division, Bhabha Atomic Research Centre (BARC), Mumbai, India.

出版信息

Appl Radiat Isot. 2022 Oct;188:110386. doi: 10.1016/j.apradiso.2022.110386. Epub 2022 Jul 31.

DOI:10.1016/j.apradiso.2022.110386

Abstract

Sm-EDTMP is widely used as a palliative radiopharmaceutical for treatment of metastatic bone pain. It is produced by neutron activation of enriched Sm targets in a nuclear reactor. The long-lived europium radionuclides are co-produced along with production of Sm and it give rise to radioactive waste in Sm-EDTMP production. The gamma radiation dose rate was found significant on the radioactive waste generated during the production of Sm-EDTMP. Residual activity in six waste samples generated in different batches of Sm-EDTMP production were analysed for percentage contributions of Eu using gamma-ray spectrometry. Eu was a major contributor with around 62%, and the other radioisotopes, viz. Eu &Eu contribution were ∼29% & ∼9% respectively. The activity concentration of these long-lived europium radionuclides in samarium radiopharmaceutical production waste may be utilised for the dose rate estimation, and vice versa.

摘要

Sm-EDTMP 被广泛用作治疗转移性骨痛的姑息性放射性药物。它是通过在核反应堆中用中子激活浓缩的 Sm 靶材来生产的。在生产 Sm 的同时也会产生长寿命的铕放射性核素，这导致了 Sm-EDTMP 生产过程中的放射性废物。在 Sm-EDTMP 生产过程中产生的放射性废物的γ辐射剂量率被发现是显著的。使用γ射线谱法分析了不同批次 Sm-EDTMP 生产过程中产生的六个废物样本的残留活性，以分析 Eu 的百分比贡献。Eu 是主要贡献者，约占 62%，其他放射性同位素，即 Eu 和 Eu 的贡献分别约为 29%和 9%。这些长寿命铕放射性核素在钐放射性药物生产废物中的活度浓度可用于剂量率估算，反之亦然。