共轭亚油酸补充剂对成年人血压和内皮功能的影响：系统评价和剂量反应荟萃分析。
The effects of conjugated linoleic acid supplementation on blood pressure and endothelial function in adults: A systematic review and dose-response meta-analysis.
机构信息
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Cellular and Molecular Nutrition, Faculty of Nutrition Science and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, 1981619573, Tehran, Iran.
出版信息
Eur J Pharmacol. 2022 Sep 15;931:175162. doi: 10.1016/j.ejphar.2022.175162. Epub 2022 Aug 5.
BACKGROUND
Findings of studies investigating the effect of conjugated linoleic acid (CLA) supplementation on blood pressure (BP) and endothelial function are controversial.
METHOD
This meta-analysis of randomized controlled trials (RCTs) was performed to explore the effects of CLA supplementation on BP and endothelial function. Two authors independently searched electronic databases using PubMed, Web of Science, and Scopus until March 2022, in order to find relevant RCTs.
RESULTS
Eighteen RCTs with 20 effect sizes met the inclusion criteria and were eligible for meta-analysis. CLA supplementation did not significantly alter systolic blood pressure (SBP) (WMD: -0.48; 95% CI: -3.23, 2.27), diastolic blood pressure (DBP) (WMD: -0.71; 95% CI: -3.54, 2.12), and vascular cell adhesion molecule (VCAM) (WMD: -34.02; 95% CI: -88.08, 20.03) levels. However, CLA supplementation significantly reduced intercellular adhesion molecule (ICAM) (WMD: -8.02; 95% CI: -13.95, -2.09) level.
CONCLUSION
This systematic review and meta-analysis showed CLA association with reduction of ICAM. The PROSPERO registration number: CRD42022331108.
背景
关于共轭亚油酸（CLA）补充剂对血压（BP）和血管内皮功能影响的研究结果存在争议。
方法
本系统评价和荟萃分析旨在探讨 CLA 补充剂对 BP 和血管内皮功能的影响，共纳入了 18 项随机对照试验（RCTs）。两位作者独立检索了 PubMed、Web of Science 和 Scopus 等电子数据库，检索时间截至 2022 年 3 月。
结果
共有 18 项 RCT 符合纳入标准并纳入荟萃分析，CLA 补充剂对收缩压（SBP）（WMD：-0.48；95%CI：-3.23，2.27）、舒张压（DBP）（WMD：-0.71；95%CI：-3.54，2.12）和血管细胞黏附分子（VCAM）（WMD：-34.02；95%CI：-88.08，20.03）水平没有显著影响。然而，CLA 补充剂可显著降低细胞间黏附分子（ICAM）（WMD：-8.02；95%CI：-13.95，-2.09）水平。
结论
本系统评价和荟萃分析表明 CLA 与 ICAM 降低有关。PROSPERO 注册号：CRD42022331108。
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