靶向利用天然产物治疗神经紊乱中的内质网应激。
Targeting endoplasmic reticulum stress using natural products in neurological disorders.
机构信息
Department of Pharmaceutical Sciences, Central University of Haryana, Mahendergarh 123031, Haryana, India.
Department of Biology, University of Saskatchewan,112 Science Place, Saskatoon, SK S7N 5E2, Canada.
出版信息
Neurosci Biobehav Rev. 2022 Oct;141:104818. doi: 10.1016/j.neubiorev.2022.104818. Epub 2022 Aug 5.
The primary aim of this review is to summarize the literature on natural products that are effective in the treatment of various neurological disorders by targeting endoplasmic reticulum stress (ERS). Various electronic databases such as SCOPUS, PubMed, Web of Science, and Google Scholar were searched for relevant publications. ERS has been implicated in the pathogenesis of numerous neurological disorders such as cerebral ischemia, Parkinson's disease, and Alzheimer's disease. Several natural products targeting ERS signalling pathways provide therapeutic options for neurological diseases, and in this review, the potential neuroprotective properties of these products are discussed.
本次综述的主要目的是总结通过靶向内质网应激（ERS）来治疗各种神经障碍的天然产物方面的文献。我们检索了 SCOPUS、PubMed、Web of Science 和 Google Scholar 等各种电子数据库，以寻找相关出版物。ERS 与许多神经障碍的发病机制有关，如脑缺血、帕金森病和阿尔茨海默病。几种靶向 ERS 信号通路的天然产物为神经疾病提供了治疗选择，在本次综述中，讨论了这些产物的潜在神经保护特性。
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