表皮是小鼠中tabby（Ta）基因的作用位点。

Epidermis is the site of action of tabby (Ta) in the mouse.

作者信息

Mayer T C, Green M C

出版信息

Genetics. 1978 Sep;90(1):125-31. doi: 10.1093/genetics/90.1.125.

DOI:10.1093/genetics/90.1.125

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1213871/

Abstract

The site of action of the sex-linked tabby (Ta) locus was analyzed by the technique of dermal-epidermal recombination grafting. Skin components from normal and tabby 14-day embryos were separated, recombined and grown 21 days in testes of histocompatible mice. Grafts of the combinations normal epidermis-normal dermis and normal epidermis-tabby dermis produced predominantly zig-zag hairs. Grafts of the combination tabby epidermis-normal dermis and tabby epidermis-tabby dermis produced hairs with a morphology similar to hairs found in tabby mice. We conclude from these results that the tabby locus acts within the epidermis, and has no effect on the dermis.

摘要

采用真皮-表皮重组移植技术分析了性连锁虎斑（Ta）基因座的作用位点。将正常和虎斑14日龄胚胎的皮肤成分分离、重组，并在组织相容性小鼠的睾丸中培养21天。正常表皮-正常真皮和正常表皮-虎斑真皮组合的移植主要产生锯齿状毛发。虎斑表皮-正常真皮和虎斑表皮-虎斑真皮组合的移植产生的毛发形态与虎斑小鼠中的毛发相似。从这些结果我们得出结论，虎斑基因座在表皮内起作用，对真皮没有影响。

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本文引用的文献

1

Genes and genotypes affecting the teeth of the mouse.影响小鼠牙齿的基因和基因型。

J Embryol Exp Morphol. 1965 Oct;14(2):137-59.

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The site of action of the fuzzy locus (fz) in the mouse, as determined by dermal-epidermal recombinations.通过真皮-表皮重组确定的小鼠模糊位点（fz）的作用位点。

J Embryol Exp Morphol. 1974 Dec;32(3):707-13.

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Genetic activity of sex chromosomes in somatic cells of mammals.

Philos Trans R Soc Lond B Biol Sci. 1970 Aug 6;259(828):41-52. doi: 10.1098/rstb.1970.0044.

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Evidence from chimaeras for the pattern of proliferation of epidermis in the mouse.

Genet Res. 1977 Jun;29(3):279-84. doi: 10.1017/s0016672300017353.

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Depilated (dep), a mutant gene that affects the coat of the mouse and acts in the epidermis.脱毛（dep），一个影响小鼠皮毛且在表皮起作用的突变基因。

Genetics. 1976 Sep;84(1):59-65. doi: 10.1093/genetics/84.1.59.

6

Site of action of the crinkled (cr) locus in the mouse.小鼠中卷曲（cr）基因座的作用位点。

Dev Biol. 1977 Feb;55(2):397-401. doi: 10.1016/0012-1606(77)90183-x.

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