Cao Xinyi, Liao Wang, Wang Shaokang
Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, Jiangsu, China.
Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, Jiangsu, China.
Adv Food Nutr Res. 2022;101:277-307. doi: 10.1016/bs.afnr.2022.04.004. Epub 2022 Jul 20.
Dietary intervention via modifications of dietary pattern or supplementations of naturally derived bioactive compounds has been considered as an efficient approach in management of nutrition related chronic diseases. Food protein-derived bioactive peptide is representative of natural compounds which show the potential to prevent or mitigate nutrition related chronic diseases. In the past decades, substantial research has been conducted concentrating on the characterization, bioavailability, and activity assessment of bioactive peptides. Although various activities of bioactive peptides have been reported, the activity testes of most peptides were only conducted in cells and animal models. Some clinical trials of bioactive peptides were also reported but only limited to antihypertensive peptides, antidiabetic peptides and peptides modulating blood lipid profile. Hereby, clinical evidence of bioactive peptides in management of nutrition-related chronic diseases is summarized in this chapter, which aims at providing implications for the clinical studies of bioactive peptides in the future.
通过改变饮食模式或补充天然来源的生物活性化合物进行饮食干预,已被视为管理营养相关慢性病的有效方法。食物蛋白衍生的生物活性肽是天然化合物的代表,显示出预防或减轻营养相关慢性病的潜力。在过去几十年中,人们进行了大量研究,重点关注生物活性肽的表征、生物利用度和活性评估。尽管已报道了生物活性肽的各种活性,但大多数肽的活性测试仅在细胞和动物模型中进行。也有一些关于生物活性肽的临床试验报道,但仅限于抗高血压肽、抗糖尿病肽和调节血脂的肽。因此,本章总结了生物活性肽在管理营养相关慢性病方面的临床证据,旨在为未来生物活性肽的临床研究提供启示。