癫痫发作后大鼠脑脊液中的乙酰胆碱酯酶活性升高；黑质损伤对这种升高及癫痫发作阈值的影响。
Acetylcholinesterase activity rises in rat cerebrospinal fluid post-ictally; effect of a substantia nigra lesion on this rise and on seizure threshold.
作者信息
Appleyard M E, Green A R, Greenfield S A
出版信息
Br J Pharmacol. 1987 May;91(1):149-54. doi: 10.1111/j.1476-5381.1987.tb08993.x.
Abstract
The activity of acetylcholinesterase (AChE) in the cerebrospinal fluid (CSF) of rats increased by 53% following an electroconvulsive shock (ECS) while non-specific cholinesterase (nsChE) activity was unchanged. A flurothyl-induced seizure failed to elicit a change in the AChE activity of CSF. A bilateral lesion of the substantia nigra pars reticulata abolished the rise in AChE activity in the CSF but did not diminish the increase of seizure threshold which follows a convulsion. These data suggest that AChE is released from the substantia nigra following a seizure but indicate that the change is not associated with the rise in seizure threshold which occurs.
摘要
电休克（ECS）后，大鼠脑脊液（CSF）中乙酰胆碱酯酶（AChE）的活性增加了53%，而非特异性胆碱酯酶（nsChE）的活性未发生变化。氟替尔诱发的癫痫发作未能引起脑脊液中AChE活性的改变。黑质网状部的双侧损伤消除了脑脊液中AChE活性的升高，但并未降低惊厥后癫痫阈值的升高。这些数据表明，癫痫发作后AChE从黑质释放，但表明这种变化与所发生的癫痫阈值升高无关。
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