Department of Food Quality and Safety/National R&D Center for Chinese Herbal Medicine Processing, College of Engineering, China Pharmaceutical University, Nanjing, Jiangsu 211198, China.
School of Life Science, Shaoxing University, Shaoxing, Zhejiang 312000, China.
Food Res Int. 2022 Sep;159:111574. doi: 10.1016/j.foodres.2022.111574. Epub 2022 Jun 27.
Titanium dioxide (TiO) is commonly used as food whitening in candies, chocolates, and cakes with high carbohydrate contents. The potential interaction between the food carbohydrate and food grade TiO nanoparticle was little known. Therefore, we explored the interaction between TiO nanoparticles and seven common carbohydrates, including monosaccharides, disaccharides, and polysaccharides. The result showed that all the carbohydrates tested interacted with the surfaces of the TiO nanoparticles and formed biocoronas. TEM and SEM images provided information about the morphology formation of biocoronas. The surface potential and size of the TiO nanoparticles altered after interacting with the carbohydrates. FTIR spectroscopy and QCM-D findings showed insights into the molecular origin and nature interaction between TiO and carbohydrates. The results illustrated that TiO nanoparticles can interact with carbohydrates, enter the body as a food additive, and interact with food matrix for a series of reactions. Compared with monosaccharides or disaccharides, food polysaccharides have stronger adsorption on the surface of nanoparticles. This is a preliminary judgment for the subsequent in vitro simulated digestion. Our result could be useful for understanding and controlling the behavior of nanoparticles in food and the human gut.
二氧化钛（TiO）常用于糖果、巧克力和高碳水化合物含量的蛋糕中的食品增白剂。食品碳水化合物和食品级 TiO 纳米颗粒之间的潜在相互作用知之甚少。因此，我们探索了 TiO 纳米颗粒与七种常见碳水化合物（包括单糖、二糖和多糖）之间的相互作用。结果表明，所有测试的碳水化合物都与 TiO 纳米颗粒的表面相互作用并形成了生物冠。TEM 和 SEM 图像提供了有关生物冠形态形成的信息。纳米颗粒与碳水化合物相互作用后，表面电势和尺寸发生了变化。FTIR 光谱和 QCM-D 的结果揭示了 TiO 和碳水化合物之间的分子起源和相互作用的本质。结果表明，TiO 纳米颗粒可以与碳水化合物相互作用，作为食品添加剂进入人体，并与食物基质发生一系列反应。与单糖或二糖相比，食物多糖在纳米颗粒表面具有更强的吸附能力。这是对后续体外模拟消化的初步判断。我们的结果有助于理解和控制纳米颗粒在食品和人体肠道中的行为。
