百日咳毒素和锂对心房和回肠毒蕈碱反应的不同作用：受体异质性的证据。
Differential effects of pertussis toxin and lithium on muscarinic responses in the atria and ileum: evidence for receptor heterogeneity.
作者信息
Eglen R M, Huff M M, Montgomery W W, Whiting R L
出版信息
Br J Pharmacol. 1987 May;91(1):6-8. doi: 10.1111/j.1476-5381.1987.tb08976.x.
Abstract
Pretreatment with pertussin toxin was shown to inhibit selectively muscarinic responses in the atria, but have no effect on responses in the ileum. The converse was true when the animals were pretreated with lithium. These data are consistent with the hypothesis that muscarinic receptors in the atria are coupled to an inhibition of adenylate cyclase, whilst those in the ileum are coupled to inositol phospholipid hydrolysis and indicate differences in the muscarinic receptors in these two tissues.
摘要
已表明用百日咳毒素预处理可选择性抑制心房中的毒蕈碱反应，但对回肠中的反应无影响。当用锂预处理动物时，情况则相反。这些数据与以下假设一致：心房中的毒蕈碱受体与腺苷酸环化酶的抑制偶联，而回肠中的毒蕈碱受体与肌醇磷脂水解偶联，这表明这两种组织中毒蕈碱受体存在差异。
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