Chen Kejie, Xiao Xiapeng, Xu Zhiping
Ningde Municipal Hospital of Ningde Normal University, Department of General Surgery, Ningde, Fujian, People's Republic of China.
Ningde Municipal Hospital of Ningde Normal University, Department of Oncology Surgery, Ningde, Fujian, People's Republic of China.
Bull Cancer. 2022 Oct;109(10):999-1006. doi: 10.1016/j.bulcan.2022.02.017. Epub 2022 Aug 6.
Breast cancer (BC) is the most diagnosed carcinoma in women worldwide, which is characterized with a high incidence rate and poor prognosis. MicroRNAs (miRNAs) are promising biomarkers for early detection of BC. In this study, we demonstrated that MiR1294 was downregulated in BC. Moreover, we revealed that MiRNA1294 significantly suppressed cell proliferation, migration and invasion. Animal models revealed that MiRNA1294 reduced tumor formation. In addition, we found that ERK signaling was involved in the regulatory role of MiRNA1294 in BC. In conclusion, MiRNA1294 acted as a tumor suppressor in BC, which might serve as a potential target for the development of anti-neoplastic therapies in BC.
乳腺癌（BC）是全球女性中诊断最多的癌症，其特点是发病率高且预后差。微小RNA（miRNA）是用于早期检测BC的有前景的生物标志物。在本研究中，我们证明MiR1294在BC中表达下调。此外，我们发现MiRNA1294显著抑制细胞增殖、迁移和侵袭。动物模型显示MiRNA1294减少肿瘤形成。此外，我们发现ERK信号通路参与MiRNA1294在BC中的调节作用。总之，MiRNA1294在BC中起肿瘤抑制作用，这可能作为BC抗肿瘤治疗开发的潜在靶点。
