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The anti-inflammatory properties of the methanolic extract of Linn. against prostate enlargement in Wistar rats.

作者信息

Rajasree R S, Ittiyavirah Sibi P, Poonkuzhi Naseef Punnoth, Saheer Kuruniyan Mohamed, Elayadeth-Meethal Muhammed, Sankar S

机构信息

College of Pharmaceutical Sciences, Government Thirumala Devaswom Medical College, Alappuzha 688005, India.

Department of Pharmaceutical Sciences, Centre for Professional and Advanced Sciences Cheruvandoor, Kottayam 686631, India.

出版信息

Saudi J Biol Sci. 2022 Sep;29(9):103396. doi: 10.1016/j.sjbs.2022.103396. Epub 2022 Jul 25.


DOI:10.1016/j.sjbs.2022.103396
PMID:35942162
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9356295/
Abstract

In different parts of the world, Linn. () is used for its medicinal properties. The present study examined the effects of a methanolic extract of Linn. (F1 hybrid, MECM) on benign prostatic hyperplasia in adult male Wistar rats and evaluated its anti-inflammatory activity . MECM treatment reduced prostate weight mildly. Histopathological studies showed that the extract produced a strong protective effect against the development of BPH by testosterone. The MECM also showed protection from testosterone-induced benign prostatic hyperplasia (BPH). MECM was tested against carrageenan-induced inflammation in rats' paws to determine its anti-inflammatory activity. It was shown that MECM had a pronounced effect on the inflammatory response in the late phase, i.e., one hour after carrageenan injection. Prostaglandins and nitric oxide are primarily responsible for this phase indicating that MECM can modify the production and release of prostaglandin and nitric oxide. A novel formulation containing may be able to treat the conditions mentioned above.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a697/9356295/be28ae1b9aab/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a697/9356295/6799fd6d3d10/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a697/9356295/6d62339bf637/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a697/9356295/0d8503003f15/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a697/9356295/be28ae1b9aab/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a697/9356295/6799fd6d3d10/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a697/9356295/6d62339bf637/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a697/9356295/0d8503003f15/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a697/9356295/be28ae1b9aab/gr4.jpg

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The anti-inflammatory properties of the methanolic extract of Linn. against prostate enlargement in Wistar rats.

Saudi J Biol Sci. 2022-9

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引用本文的文献

[1]
Thymoquinone-rich black cumin oil attenuates ibotenic acid-induced excitotoxicity through glutamate receptors in Wistar rats.

Saudi Pharm J. 2022-12

本文引用的文献

[1]
Green Solvents Combined with Bioactive Compounds as Delivery Systems: Present Status and Future Trends.

ACS Appl Bio Mater. 2021-5-17

[2]
Plant-Based Antioxidant Extracts and Compounds in the Management of Oral Cancer.

Antioxidants (Basel). 2021-8-26

[3]
Aerobic exercises ameliorate benign prostatic hyperplasia via IGF-1/IGF-1R/ERK/AKT signalling pathway in prostate tissue of high-fat-diet-fed mice with insulin resistance.

Steroids. 2021-11

[4]
Diacerein ameliorates testosterone-induced benign prostatic hyperplasia in rats: Effect on oxidative stress, inflammation and apoptosis.

Int Immunopharmacol. 2021-11

[5]
The prostaglandin pathway is activated in patients who fail medical therapy for benign prostatic hyperplasia with lower urinary tract symptoms.

Prostate. 2021-9

[6]
Genotypic analysis of the female BPH/5 mouse, a model of superimposed preeclampsia.

PLoS One. 2021

[7]
Smoothened inhibition leads to decreased cell proliferation and suppressed tissue fibrosis in the development of benign prostatic hyperplasia.

Cell Death Discov. 2021-5-18

[8]
Flavonoids Alleviate Peripheral Neuropathy Induced by Anticancer Drugs.

Cancers (Basel). 2021-3-29

[9]
Anti-inflammatory effect of leaves of Vernonia zeylanica in lipopolysaccharide-stimulated RAW 264.7 macrophages and carrageenan-induced rat paw-edema model.

J Ethnopharmacol. 2021-6-28

[10]
Neuromodulation by the immune system: a focus on cytokines.

Nat Rev Immunol. 2021-8

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