血清素通过百日咳毒素底物降低海马细胞群体峰电位幅度。
Serotonin decreases population spike amplitude in hippocampal cells through a pertussis toxin substrate.
作者信息
Clarke W P, De Vivo M, Beck S G, Maayani S, Goldfarb J
出版信息
Brain Res. 1987 May 5;410(2):357-61. doi: 10.1016/0006-8993(87)90338-6.
PMID:3594245
Abstract
Activation of the serotonin1A receptor decreases CA1 population spike amplitude and inhibits forskolin-stimulated adenylate cyclase in rat hippocampus. Pretreatment of rats with pertussis toxin blocked both responses. Because the electrophysiological and biochemical responses to serotonin were correlated after pertussis toxin treatment, we conclude that both responses are mediated by a common regulatory protein, presumably Gi.
摘要
血清素1A受体的激活会降低大鼠海马体中CA1群体峰电位的幅度，并抑制福斯高林刺激的腺苷酸环化酶。用百日咳毒素预处理大鼠可阻断这两种反应。由于在百日咳毒素处理后，对血清素的电生理和生化反应是相关的，我们得出结论，这两种反应均由一种共同的调节蛋白介导，推测为Gi。
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