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患者膀胱癌和上尿路尿路上皮癌行肾输尿管切除术后,因膀胱内灌注卡介苗(BCG)导致结核性腹膜炎:病例报告。

Peritoneal tuberculosis caused by intravesical instillation with Bacillus Calmette-Guérin (BCG) following nephroureterectomy in a patient with bladder and upper tract urothelial cancer: a case report.

机构信息

Department of Urology, Ghent University Hospital, Ghent, Belgium.

Department of General Internal Medicine, Ghent University Hospital, Ghent, Belgium.

出版信息

Acta Clin Belg. 2023 Jun;78(3):257-260. doi: 10.1080/17843286.2022.2110688. Epub 2022 Aug 9.

DOI:10.1080/17843286.2022.2110688
PMID:35943041
Abstract

BACKGROUND

The standard treatment for high-risk non-muscle-invasive bladder cancer (NMIBC) is trans-urethral resection of the bladder (TURB) followed by instillation of Bacillus Calmette-Guérin (BCG). The occurrence of peritoneal tuberculosis after intravesical BCG instillation is extremely rare and difficult to diagnose.

METHODS

We report the case of a 79-year-old man with urothelial cell carcinoma (UCC) of the kidney and bladder who developed peritoneal tuberculosis after consecutive TURB and nephroureterectomy followed by intravesical BCG instillation. Further investigation revealed an undiagnosed bladder leak.

CONCLUSION

This case serves as a reminder for urologists to be suspicious for urothelium discontinuity when administering BCG shortly after bladder surgery.

摘要

背景

高危非肌肉浸润性膀胱癌(NMIBC)的标准治疗方法是经尿道膀胱肿瘤切除术(TURB),然后膀胱内灌注卡介苗(BCG)。膀胱内灌注 BCG 后发生腹膜结核极为罕见,且难以诊断。

方法

我们报告了一例 79 岁男性,患有肾和膀胱尿路上皮细胞癌(UCC),在连续进行 TURB 和肾输尿管切除术,然后膀胱内灌注 BCG 后发生腹膜结核。进一步的调查显示存在未确诊的膀胱漏。

结论

该病例提醒泌尿科医生在膀胱手术后不久给予 BCG 时要怀疑尿路上皮连续性中断。

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