肝脾比值：能否用于预测冠状动脉疾病？
Liver-Spleen Ratio: Can It Be Used for the Prediction of Coronary Artery Disease?
机构信息
Department of Radiology, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
Department of Nephrology, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
出版信息
Anatol J Cardiol. 2022 Oct;26(10):762-770. doi: 10.5152/AnatolJCardiol.2022.1787.
BACKGROUND
Considering that ectopic fat accumulation in various organs, especially the heart and liver, is a cardiometabolic risk factor, the need for easily accessible markers of ectopic fat accumulation is inevitable. The main starting point of the study is based on the hypothesis of predicting cardiovascular disease risk through the link that can be established between the liver-spleen ratio, which is one of the strong indicators of hepa- tosteatosis, and epicardial adipose tissue volume.
METHODS
This was a retrospective study. The records of 283 consecutive patients who underwent coronary computed tomography angiography in our Radiology Department were reviewed retrospectively from our hospital's system. All patients' epicardial adipose tissue volume and liver-spleen ratio were calculated using appropriate criteria on non- contrast computed tomography images. Additionally, the Coronary Artery Disease- Reporting and Data System was calculated on contrast computed tomography images. The participating patients were divided into groups according to the liver-spleen ratio and Coronary Artery Disease-Reporting and Data System score.
RESULTS
We found that while there was a negative correlation between the liver-spleen ratio and epicardial adipose tissue volume in the hepatosteatosis group, this relationship was not observed in the non-steatosis group. In addition, we observed that the family his- tory of cardiovascular disease and the frequency of cardiovascular disease were higher in the hepatosteatosis group than in the other group, and there was a correlation between cardiovascular disease and the liver-spleen ratio. Also, we found that age and liver- spleen ratio values were found to be independent predictors of coronary artery disease.
CONCLUSION
In our study, we found that the frequency of cardiovascular disease was lower in patients with a high liver-spleen ratio. We also demonstrated in the study that the liver-spleen ratio, which indicates a low level of epicardial adipose tissue volume accumulation, is an independent predictor of cardiovascular disease. In addition, the use of liver-spleen ratio, which is more valuable than liver attenuation in predicting hepatic steatosis, may be more useful in evaluating the risk of hepatosteatosis-related cardio- vascular disease.
背景
考虑到各种器官（尤其是心脏和肝脏）的异位脂肪堆积是心血管代谢风险因素，因此需要易于获取的异位脂肪堆积标志物。本研究的主要出发点是基于这样一种假设，即通过可以建立肝脾比值（肝脂肪变性的一个强有力指标）与心外膜脂肪组织体积之间的联系，来预测心血管疾病风险。
方法
这是一项回顾性研究。我们回顾性地查阅了我院放射科连续 283 例接受冠状动脉计算机断层扫描血管造影的患者的记录。使用非对比计算机断层扫描图像上的适当标准计算所有患者的心外膜脂肪组织体积和肝脾比值。此外，还根据对比计算机断层扫描图像计算了冠状动脉疾病报告和数据系统。根据肝脾比值和冠状动脉疾病报告和数据系统评分将患者分为两组。
结果
我们发现，在肝脂肪变性组中，肝脾比值与心外膜脂肪组织体积之间存在负相关，但在非脂肪变性组中未观察到这种关系。此外，我们观察到在肝脂肪变性组中，心血管疾病家族史和心血管疾病的发生频率高于其他组，并且心血管疾病与肝脾比值之间存在相关性。另外，我们发现年龄和肝脾比值值被认为是冠心病的独立预测因子。
结论
在我们的研究中，我们发现肝脾比值高的患者心血管疾病的发生频率较低。我们还在研究中证明，肝脾比值（提示心外膜脂肪组织体积积累水平低）是心血管疾病的独立预测因子。此外，使用肝脾比值（其在预测肝脂肪变性方面比肝衰减更有价值）可能更有助于评估与肝脂肪变性相关的心血管疾病风险。
Zotero 插件