Seder R H, Vaughan C W, Oh S K, Keggins J J, Hayes J A, Blanchard G C, Vincent M E, Katz A E
Cancer. 1987 Aug 1;60(3):318-25. doi: 10.1002/1097-0142(19870801)60:3<318::aid-cncr2820600308>3.0.co;2-3.
A major response to plasmapheresis is reported in a patient with advanced, recurrent squamous cell cancer of the oral cavity, similar to that previously reported in three of six comparable patients. Tumor regression followed temporary reduction of inhibition of normal lymphocyte response to phytohemagglutinin (PHA) by the patient's serum (from 99% to zero) and partial restoration of the patient's lymphocyte response (from 2% to 38% of control). The IgE level rose both overall and during some exchanges; this correlate of tumor response had been noted earlier. The tumor showed extensive necrosis, but the clinical effects were relatively short-lived and the patient died 11 weeks later. Biopsy specimens taken early in apheresis showed intense new infiltration of tumor by lymphocytes and monocytes; later biopsy specimens showed predominantly plasma cells with trapping and lysis of tumor cells. No other anti-cancer therapies had been used for 16 months before this trial, and no replacements were given other than saline and albumin.
据报道，一名患有晚期复发性口腔鳞状细胞癌的患者对血浆置换有显著反应，这与之前六名类似患者中的三名所报告的情况相似。肿瘤消退之前，患者血清对正常淋巴细胞对植物血凝素（PHA）反应的抑制作用暂时降低（从99%降至零），患者淋巴细胞反应部分恢复（从对照的2%升至38%）。IgE水平总体上升，并且在一些置换过程中也有所上升；肿瘤反应的这种关联早有记载。肿瘤显示出广泛坏死，但临床效果相对短暂，患者在11周后死亡。血浆置换早期采集的活检标本显示肿瘤有大量新的淋巴细胞和单核细胞浸润；后来的活检标本显示主要是浆细胞，伴有肿瘤细胞的捕获和溶解。在该试验前16个月未使用其他抗癌疗法，除生理盐水和白蛋白外未给予其他替代物。
