In the Department of Family Medicine at the Mayo Clinic in Rochester, Minn., Joshua D. Luciew practices in family medicine and is an instructor and codirector of family medicine grand rounds, Rodney A. Erickson is a consultant and assistant professor, and Tara K. Kaufman i s a consultant and assistant professor. The authors have disclosed no potential conflicts of interest, financial or otherwise.
JAAPA. 2022 Sep 1;35(9):19-24. doi: 10.1097/01.JAA.0000854524.40560.f3.
COVID-19 quickly escalated to a global pandemic in 2020. As research on the topic continues, the medical community has found that this acute illness can cause a new chronic illness: postacute sequelae of SARS-CoV-2 (PASC). Some patients with PASC develop predominately neurologic sequelae (post-COVID-19 neurologic syndrome or PCNS). This article describes PASC and PCNS, their proposed pathogenicity and possible neurovirulence mechanisms, symptoms, and treatment recommendations.
2020 年，COVID-19 迅速升级为全球大流行。随着对该主题的研究不断深入，医学界发现这种急性疾病可导致新的慢性疾病：SARS-CoV-2 后急性后遗症（PASC）。一些 PASC 患者出现以神经系统后遗症为主（新冠后神经综合征或 PCNS）。本文描述了 PASC 和 PCNS 及其推测的发病机制和可能的神经毒力机制、症状和治疗建议。
