解析三聚体胶原蛋白 I 的致癌作用。
Untangling the tumorigenic role of homotrimeric collagen I.
机构信息
Systems Oncology, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Manchester, SK10 4TG, UK.
出版信息
Cancer Cell. 2022 Aug 8;40(8):802-804. doi: 10.1016/j.ccell.2022.07.007.
PMID:35944498
Abstract
Pancreatic ductal adenocarcinoma is characterized by a complex microenvironment. In this issue of Cancer Cell, Chen and colleagues define an oncogenic role of tumor-cell-produced collagen I homotrimers, wherein tumor development is promoted by integrin α3/β1-dependent activation of tumor cell signaling and modulation of tumor microbiome and immunity.
摘要
胰腺导管腺癌的特征是存在复杂的微环境。在本期《癌细胞》杂志中，Chen 和同事们定义了肿瘤细胞产生的胶原 I 三聚体的致癌作用，即肿瘤的发展是通过整合素 α3/β1 依赖性激活肿瘤细胞信号以及调节肿瘤微生物组和免疫来促进的。
Zotero 插件