HT-29人结肠腺癌细胞系对肿瘤的体内延迟排斥反应及对迟发型超敏反应的抑制作用。

In vivo delayed rejection of tumors and inhibition of delayed-type hypersensitivity by HT-29 human colonic adenocarcinoma cell line.

作者信息

Pommier G J, Garrouste F L, Bettetini D, Culouscou J M, Remacle-Bonnet M M

出版信息

Cancer Immunol Immunother. 1987;24(3):225-30. doi: 10.1007/BF00205634.

DOI:10.1007/BF00205634

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11038160/

Abstract

Products secreted by HT-29 human colonic adenocarcinoma cells (DMEM-HT-29) mediated strong suppressive activity of in vitro lymphoproliferative responses to several mitogens. In vivo administration of DMEM-HT-29 both inhibited the afferent limb of delayed-type hypersensitivity against the Mc FiFi2(s) syngeneic fibrosarcoma and delayed the rejection of these tumor cells by immunized animals. Transfer experiments prior or after cell fractionation did not demonstrate suppressor cells induced by DMEM-HT-29. This suggests that DMEM-HT-29 produces its effect by directly interacting with macrophage and/or T cells at the sensitization stage of the antitumor immune response.

摘要

HT-29人结肠腺癌细胞（DMEM-HT-29）分泌的产物介导了对多种有丝分裂原的体外淋巴细胞增殖反应的强烈抑制活性。体内给予DMEM-HT-29既抑制了对同基因Mc FiFi2(s)纤维肉瘤的迟发型超敏反应的传入支，又延迟了免疫动物对这些肿瘤细胞的排斥。细胞分级分离之前或之后的转移实验均未证明DMEM-HT-29诱导出抑制细胞。这表明DMEM-HT-29在抗肿瘤免疫反应的致敏阶段通过与巨噬细胞和/或T细胞直接相互作用发挥其效应。

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