Rej Supriya, Chatani Naoto
Department of Applied Chemistry, Faculty of Engineering and Research Center for Environmental Preservation, Osaka University, Suita, Osaka, 565-0871, Japan.
Institut für Chemie, Technische Universität Berlin, Strasse des 17. Juni 115, 10623, Berlin, Germany.
Angew Chem Int Ed Engl. 2022 Nov 2;61(44):e202209539. doi: 10.1002/anie.202209539. Epub 2022 Sep 23.
Considerable advances have been made in the area of C-H functionalization in the last few decades. A number of approaches including both directed and nondirected strategies have been developed thus far. Among the various C-H functionalizations, C-H borylation is of special interest due to the wide applications of organoboron compounds. In this regard, various transition-metal-catalyzed regioselective strategies have been developed. However, the major concern regarding metal-catalyzed C-H borylation procedures is the requirement of a precious metal as well as the contamination by metal precursors in the desired products, which limit the application of this process in large-scale synthesis. Therefore, recent trends have involved the use of transition-metal-free systems. We summarize recent developments in transition-metal-free regioselective C-H borylation. We believe that this Review will help to increase interest in this field and stimulate further progress.
在过去几十年里，C-H官能化领域取得了长足进展。到目前为止，已经开发了许多方法，包括定向和非定向策略。在各种C-H官能化反应中，由于有机硼化合物的广泛应用，C-H硼化反应备受关注。在这方面，已经开发了各种过渡金属催化的区域选择性策略。然而，金属催化的C-H硼化反应过程的主要问题是需要使用贵金属以及目标产物中会被金属前体污染，这限制了该方法在大规模合成中的应用。因此，最近的趋势是使用无过渡金属体系。我们总结了无过渡金属区域选择性C-H硼化反应的最新进展。我们相信这篇综述将有助于提高对该领域的兴趣并推动进一步的发展。
