Vasseur Sophie, Guillaumond Fabienne
Centre de Recherche en Cancérologie de Marseille, INSERM, Aix-Marseille Université, CNRS, Institut Paoli-Calmettes, F-13009, Marseille, France.
Oncogenesis. 2022 Aug 9;11(1):46. doi: 10.1038/s41389-022-00420-8.
Lipids are essential constituents for malignant tumors, as they are absolutely required for tumor growth and dissemination. Provided by the tumor microenvironment (TME) or by cancer cells themselves through activation of de novo synthesis pathways, they orchestrate a large variety of pro-tumorigenic functions. Importantly, TME cells, especially immune cells, cancer-associated fibroblasts (CAFs) and cancer-associated adipocytes (CAAs), are also prone to changes in their lipid content, which hinder or promote tumor aggressiveness. In this review, we address the significant findings for lipid contribution in tumor progression towards a metastatic disease and in the poor response to therapeutic treatments. We also highlight the benefits of targeting lipid pathways in preclinical models to slow down metastasis development and overcome chemo-and immunotherapy resistance.
脂质是恶性肿瘤的重要组成部分，因为它们是肿瘤生长和扩散所绝对必需的。由肿瘤微环境（TME）或癌细胞自身通过从头合成途径的激活提供，它们协调了多种促肿瘤功能。重要的是，TME细胞，尤其是免疫细胞、癌症相关成纤维细胞（CAFs）和癌症相关脂肪细胞（CAAs），其脂质含量也容易发生变化，这会阻碍或促进肿瘤的侵袭性。在这篇综述中，我们阐述了脂质在肿瘤向转移性疾病进展以及对治疗反应不佳方面的重要研究结果。我们还强调了在临床前模型中靶向脂质途径以减缓转移发展并克服化学疗法和免疫疗法耐药性的益处。
