Ferreri Carla, Ferreri Rosaria, Filippone Alessio, Rossi Maria Maddalena, Rossi Cristina, Maggiore Claudia, Di Micco Annalisa, Franceschini Gianluca, Sansone Anna, Batani Gessica, Masetti Riccardo, Magno Stefano
ISOF, Consiglio Nazionale delle Ricerche, Bologna, Italy.
Lipinutragen Lipidomic Laboratory, c/o Consiglio Nazionale delle Ricerche, Research Area, Bologna, Italy.
NPJ Breast Cancer. 2025 Jul 3;11(1):66. doi: 10.1038/s41523-025-00784-1.
Fat quality and quantity have a strong impact on cancer metabolism, however, in oncology practice, only body mass index (BMI) is evaluated. The observational prospective study performed at Fondazione Policlinico Gemelli explored the combination of membrane lipidome, BMI, and body composition, together with nutritional information, as evaluation criteria of fifty newly diagnosed early breast cancer patients (BRECALIP study). The fatty acid content of red blood cell membrane phospholipids, dividing patients by the BMI, individuated normal weight subjects for their molecular signatures different from the other groups, pointing to increased membrane fluidity and inflammation (saturated fatty acid decrease, omega-6 fatty acid increase), known to sustain cancer proliferation. Fat mass (FM% ≥30) and phase angles (PA° ≥ 5.6) in the normal weight group correlated with specific pro-inflammatory fatty acid modifications. Such patient stratification, confirmed by large and longitudinal studies, can better individuate nutritional/metabolic risks of inflammatory implications in breast cancer.
脂肪的质量和数量对癌症代谢有强烈影响，然而，在肿瘤学实践中，仅评估体重指数（BMI）。在罗马天主教圣心大学综合医院基金会进行的一项前瞻性观察研究，探讨了膜脂质组、BMI和身体成分的组合，以及营养信息，作为五十名新诊断的早期乳腺癌患者的评估标准（BRECALIP研究）。通过BMI对患者进行分组，红细胞膜磷脂的脂肪酸含量显示，正常体重受试者的分子特征与其他组不同，表明膜流动性增加和炎症（饱和脂肪酸减少，ω-6脂肪酸增加），已知这些因素会促进癌症增殖。正常体重组的脂肪量（FM%≥30）和相位角（PA°≥5.6）与特定的促炎脂肪酸修饰相关。这种患者分层经大型纵向研究证实，可以更好地确定乳腺癌中炎症相关的营养/代谢风险。
