• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

长链非编码 RNA 重编程调控因子通过表皮生长因子受体信号通路在结肠癌进展中的作用。

Role of Long Noncoding RNA Regulator of Reprogramming in Colon Cancer Progression via Epidermal Growth Factor Receptor Signaling.

机构信息

Department of Oncology, 117932Nantong City No. 1 People's Hospital and Second Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.

Research Center of Clinical Medicine, 74567The Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.

出版信息

Technol Cancer Res Treat. 2022 Jan-Dec;21:15330338221114707. doi: 10.1177/15330338221114707.

DOI:10.1177/15330338221114707
PMID:35946134
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9373180/
Abstract

Long intergenic noncoding RNA regulator of reprogramming (linc-ROR) is a novel long noncoding RNA that exhibits significant effects on cancer progression. This research presented that linc-ROR had a crucial part in promoting biological characteristics associated with worse prognosis in colon cancer. Bioinformatics analysis was performed to predict signaling pathways related to linc-ROR. In addition, western blot, quantitative reverse transcription-polymerase chain reaction, RNA-pulldown, cell proliferation assays, colony formation assays, wound healing assays, and transwell assays were applied to detect the role and regulation of particular molecules. Our results showed that the knockdown of linc-ROR reduced cell invasion, proliferative ability, and migration in colon cancer. Further evaluation verified that downregulating linc-ROR inhibited the activation of epidermal growth factor receptor (EGFR) signaling. In addition, cbl-b, a kind of E3 ubiquitin ligase that increases the degradation of EGFR, was found to be a potential linc-ROR target. Based on our findings, it was presented that linc-ROR served a role as a tumor-promoting factor via repressing the ubiquitination and degradation of EGFR signaling, which indicated that it could be a possible prognostic marker and therapeutic target for colon cancer.

摘要

长链非编码 RNA 调控重编程（linc-ROR）是一种新型长链非编码 RNA，对癌症进展有显著影响。本研究表明，linc-ROR 在促进与结直肠癌预后不良相关的生物学特征方面起着关键作用。进行了生物信息学分析以预测与 linc-ROR 相关的信号通路。此外，还应用了 Western blot、定量逆转录聚合酶链反应、RNA 下拉、细胞增殖测定、集落形成测定、划痕愈合测定和 Transwell 测定来检测特定分子的作用和调节。我们的结果表明，linc-ROR 的敲低降低了结肠癌的侵袭、增殖能力和迁移。进一步评估证实，下调 linc-ROR 抑制了表皮生长因子受体（EGFR）信号的激活。此外，cbl-b，一种增加 EGFR 降解的 E3 泛素连接酶，被发现是 linc-ROR 的潜在靶标。基于我们的发现，提出 linc-ROR 通过抑制 EGFR 信号的泛素化和降解来充当肿瘤促进因子，这表明它可能是结直肠癌的一个潜在预后标志物和治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffc6/9373180/2e28468a8b5e/10.1177_15330338221114707-fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffc6/9373180/cd8472856bad/10.1177_15330338221114707-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffc6/9373180/24e1e00d77ca/10.1177_15330338221114707-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffc6/9373180/51810e46e8d1/10.1177_15330338221114707-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffc6/9373180/be643e87cf3e/10.1177_15330338221114707-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffc6/9373180/1c284ac03cef/10.1177_15330338221114707-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffc6/9373180/6dd0752b1324/10.1177_15330338221114707-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffc6/9373180/5d8c38cd5d71/10.1177_15330338221114707-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffc6/9373180/2e28468a8b5e/10.1177_15330338221114707-fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffc6/9373180/cd8472856bad/10.1177_15330338221114707-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffc6/9373180/24e1e00d77ca/10.1177_15330338221114707-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffc6/9373180/51810e46e8d1/10.1177_15330338221114707-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffc6/9373180/be643e87cf3e/10.1177_15330338221114707-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffc6/9373180/1c284ac03cef/10.1177_15330338221114707-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffc6/9373180/6dd0752b1324/10.1177_15330338221114707-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffc6/9373180/5d8c38cd5d71/10.1177_15330338221114707-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffc6/9373180/2e28468a8b5e/10.1177_15330338221114707-fig8.jpg

相似文献

1
Role of Long Noncoding RNA Regulator of Reprogramming in Colon Cancer Progression via Epidermal Growth Factor Receptor Signaling.长链非编码 RNA 重编程调控因子通过表皮生长因子受体信号通路在结肠癌进展中的作用。
Technol Cancer Res Treat. 2022 Jan-Dec;21:15330338221114707. doi: 10.1177/15330338221114707.
2
[Expression and function of long intergenic non-protein coding RNA-regulator of reprogramming in high-grade ovarian serous cancer].[长链基因间非编码RNA-重编程调控因子在高级别浆液性卵巢癌中的表达及功能]
Zhonghua Fu Chan Ke Za Zhi. 2016 Dec 25;51(12):921-927. doi: 10.3760/cma.j.issn.0529-567X.2016.12.008.
3
Linc-RoR promotes proliferation, migration, and invasion via the Hippo/YAP pathway in pancreatic cancer cells.Linc-RoR 通过 Hippo/YAP 通路促进胰腺癌细胞的增殖、迁移和侵袭。
J Cell Biochem. 2020 Jan;121(1):632-641. doi: 10.1002/jcb.29308. Epub 2019 Aug 26.
4
Linc-ROR inhibits NK cell-killing activity by promoting RXRA ubiquitination and reducing MICB expression in gastric cancer patients.Linc-ROR 通过促进 RXRA 泛素化和降低胃癌患者 MICB 的表达来抑制 NK 细胞杀伤活性。
J Cell Biochem. 2024 Feb;125(2):e30516. doi: 10.1002/jcb.30516. Epub 2024 Jan 11.
5
SOX2-Induced Linc-ROR Upregulation Inhibits Gastric Carcinoma Cell Proliferation and Metastasis Via the miR-580-3p/ANXA10 Pathway.SOX2 诱导的 Linc-ROR 上调通过 miR-580-3p/ANXA10 通路抑制胃癌细胞增殖和转移。
Biochem Genet. 2023 Jun;61(3):1113-1127. doi: 10.1007/s10528-022-10300-w. Epub 2022 Nov 30.
6
Modulation of hypoxia-signaling pathways by extracellular linc-RoR.细胞外linc-RoR对缺氧信号通路的调节
J Cell Sci. 2014 Apr 1;127(Pt 7):1585-94. doi: 10.1242/jcs.141069. Epub 2014 Jan 24.
7
Linc-ROR regulates apoptosis in esophageal squamous cell carcinoma via modulation of p53 ubiquitination by targeting miR-204-5p/MDM2.Linc-ROR 通过靶向 miR-204-5p/MDM2 调控 p53 泛素化来调节食管鳞癌细胞凋亡。
J Cell Physiol. 2020 Mar;235(3):2325-2335. doi: 10.1002/jcp.29139. Epub 2019 Sep 20.
8
Linc-ROR targets FGF2 to regulate HASMC proliferation and migration via sponging miR-195-5p.Linc-ROR 通过海绵吸附 miR-195-5p 靶向 FGF2 调节 HASMC 增殖和迁移。
Gene. 2020 Jan 30;725:144143. doi: 10.1016/j.gene.2019.144143. Epub 2019 Oct 17.
9
Linc-ROR promotes invasion and metastasis of gastric cancer by activating epithelial-mesenchymal transition.Linc-ROR 通过激活上皮-间充质转化促进胃癌的侵袭和转移。
Indian J Pathol Microbiol. 2022 Jul-Sep;65(3):545-550. doi: 10.4103/ijpm.ijpm_696_21.
10
Linc-RoR promotes MAPK/ERK signaling and confers estrogen-independent growth of breast cancer.Linc-RoR 促进 MAPK/ERK 信号通路并赋予乳腺癌雌激素非依赖性生长的能力。
Mol Cancer. 2017 Oct 17;16(1):161. doi: 10.1186/s12943-017-0727-3.

引用本文的文献

1
The role of CBL family ubiquitin ligases in cancer progression and therapeutic strategies.CBL家族泛素连接酶在癌症进展中的作用及治疗策略。
Front Pharmacol. 2024 Jul 26;15:1432545. doi: 10.3389/fphar.2024.1432545. eCollection 2024.
2
Decoding the regulatory landscape of lncRNAs as potential diagnostic and prognostic biomarkers for gastric and colorectal cancers.解析 lncRNAs 的调控图谱作为胃癌和结直肠癌潜在的诊断和预后生物标志物。
Clin Exp Med. 2024 Jan 31;24(1):29. doi: 10.1007/s10238-023-01260-5.
3
Functional Relevance of the Long Intergenic Non-Coding RNA Regulator of Reprogramming (Linc-ROR) in Cancer Proliferation, Metastasis, and Drug Resistance.

本文引用的文献

1
Mechanisms of long non-coding RNA function in colorectal cancer tumorigenesis.长非编码 RNA 在结直肠癌发生中的作用机制。
Asia Pac J Clin Oncol. 2021 Feb;17(1):7-23. doi: 10.1111/ajco.13452. Epub 2020 Sep 24.
2
Relevance Function of Linc-ROR in the Pathogenesis of Cancer.Linc-ROR在癌症发病机制中的相关性作用
Front Cell Dev Biol. 2020 Aug 11;8:696. doi: 10.3389/fcell.2020.00696. eCollection 2020.
3
Role of non-coding RNAs as novel biomarkers for detection of colorectal cancer progression through interaction with the cell signaling pathways.
重编程长链基因间非编码RNA调节因子（Linc-ROR）在癌症增殖、转移和耐药中的功能相关性
Noncoding RNA. 2023 Jan 31;9(1):12. doi: 10.3390/ncrna9010012.
非编码 RNA 通过与细胞信号通路相互作用作为新型生物标志物在结直肠癌进展检测中的作用。
Gene. 2020 Aug 30;753:144796. doi: 10.1016/j.gene.2020.144796. Epub 2020 May 22.
4
β-Elemene inhibits the metastasis of multidrug-resistant gastric cancer cells through miR-1323/Cbl-b/EGFR pathway.β-榄香烯通过 miR-1323/Cbl-b/EGFR 通路抑制多药耐药胃癌细胞的转移。
Phytomedicine. 2020 Apr;69:153184. doi: 10.1016/j.phymed.2020.153184. Epub 2020 Feb 10.
5
Diagnostic and prognostic potential of tissue and circulating long non-coding RNAs in colorectal tumors.组织和循环长非编码 RNA 在结直肠肿瘤中的诊断和预后潜力。
World J Gastroenterol. 2019 Sep 14;25(34):5026-5048. doi: 10.3748/wjg.v25.i34.5026.
6
LncRNA FENDRR attenuates colon cancer progression by repression of SOX4 protein.长链非编码RNA FENDRR通过抑制SOX4蛋白来减弱结肠癌进展。
Onco Targets Ther. 2019 May 30;12:4287-4295. doi: 10.2147/OTT.S195853. eCollection 2019.
7
LncRNA CASC9 interacts with CPSF3 to regulate TGF-β signaling in colorectal cancer.长链非编码 RNA CASC9 与 CPSF3 相互作用，调节结直肠癌中的 TGF-β 信号通路。
J Exp Clin Cancer Res. 2019 Jun 11;38(1):249. doi: 10.1186/s13046-019-1263-3.
8
Regulation Mechanism of Long Noncoding RNAs in Colon Cancer Development and Progression.长链非编码RNA在结肠癌发生发展中的调控机制
Yonsei Med J. 2019 Apr;60(4):319-325. doi: 10.3349/ymj.2019.60.4.319.
9
LncRNA DUXAP9-206 directly binds with Cbl-b to augment EGFR signaling and promotes non-small cell lung cancer progression.长链非编码 RNA DUXAP9-206 直接与 Cbl-b 结合，增强表皮生长因子受体信号通路，促进非小细胞肺癌进展。
J Cell Mol Med. 2019 Mar;23(3):1852-1864. doi: 10.1111/jcmm.14085. Epub 2018 Dec 4.
10
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.全球癌症统计数据 2018：GLOBOCAN 对全球 185 个国家/地区 36 种癌症的发病率和死亡率的估计。
CA Cancer J Clin. 2018 Nov;68(6):394-424. doi: 10.3322/caac.21492. Epub 2018 Sep 12.