Muş State Hospital, Department of General Surgery - Muş, Turkey.
Atatürk University Faculty of Medicine, Department of General Surgery - Erzurum, Turkey.
Rev Assoc Med Bras (1992). 2022 Jul;68(7):888-892. doi: 10.1590/1806-9282.20211188.
Gastric cancer ranks the third among the cancer-related deaths. It is diagnosed at advanced stage in many patients due to malignant proliferation and has a poor prognosis. Currently, no instrument or biomarker has been proven to diagnose the disease before the advanced stages. This study aimed to measure the serum levels of galanin and obestatin, which were examined in various studies including cancer studies, and to discuss their diagnostic value in gastric cancers.
In this study, 30 adult patients with gastric cancer and 30 healthy adults in the control group were examined prospectively. The demographic characteristics and serum levels of galanin and obestatin in the patient and control groups were recorded.
The mean serum level of galanin in the patient and control groups was 19.73±5.04 and 35.59±10.94 pg/mL, respectively. The mean serum level of obestatin in the patient and control groups was 40.21±5.82 and 15.15±3.32 ng/mL, respectively. A significant difference was found between the groups (p<0.001).
Serum levels of galanin were lower and serum levels of obestatin were higher in patients with gastric cancer compared to the healthy individuals. Serum levels of obestatin and galanin can be used as potential biomarkers in the diagnosis of gastric cancer.
胃癌在癌症相关死亡中排名第三。由于恶性增殖，许多患者在晚期才被诊断出来，预后较差。目前，没有仪器或生物标志物被证明可以在晚期之前诊断这种疾病。本研究旨在测量甘丙肽和肥胖抑制素的血清水平，这些物质在包括癌症研究在内的各种研究中都有检查，并讨论它们在胃癌中的诊断价值。
本研究前瞻性地检查了 30 名成年胃癌患者和 30 名健康成年人对照组。记录了患者和对照组的人口统计学特征以及甘丙肽和肥胖抑制素的血清水平。
患者组和对照组的甘丙肽血清平均水平分别为 19.73±5.04 和 35.59±10.94 pg/mL。患者组和对照组的肥胖抑制素血清平均水平分别为 40.21±5.82 和 15.15±3.32 ng/mL。两组间存在显著差异（p<0.001）。
与健康个体相比，胃癌患者的甘丙肽血清水平较低，肥胖抑制素血清水平较高。肥胖抑制素和甘丙肽的血清水平可以作为胃癌诊断的潜在生物标志物。
