Bardellini Elena, Amadori Francesca, Veneri Federica, Albini Giorgia, Porta Fulvio, Alessandra Majorana
Department of Medical and Surgical Specialities, Radiological Sciences and Public Health, School of Pediatric Dentistry, University of Brescia, Brescia, Italy.
Oncology-Hematology and BMT Unit, Ospedale dei Bambini, ASST Spedali Civili di Brescia, Brescia, Italy.
Oral Dis. 2023 Oct;29(7):2705-2709. doi: 10.1111/odi.14344. Epub 2022 Aug 30.
Children undergoing chemotherapy can experience dysphagia due to non-erosive reflux disease (NERD). Oral mucositis (OM) associated with NERD-dysphagia in children with cancer has recently been defined with the acronym COMEDY (Clenching, Oral Mucositis, closed Eyes, DYsphagia). This study aims to identify the prevalence of the COMEDY pattern among chemotherapy-induced OM.
Forty-two medical records of children undergoing chemotherapy for haemato-oncologic diseases and presenting OM were reviewed. The following data were collected: age, type of haemato-oncologic disease, presence of dysphagia, type of oral mucosal lesions (i.e. traditional oral mucositis or COMEDY pattern), site of oral lesions, ear-nose-throat (ENT) assessment for the indirect signs of NERD and paediatric neuro-psychiatric (PNP) assessment.
Among 42 children with chemotherapy-related OM, 6 patients (14.2%) showed the COMEDY pattern. Besides the characteristic clinical aspect of the oral mucosa, initially classified as grade II OM, these children suffered from NERD-related dysphagia and PNP issues.
A COMEDY pattern can occur in a number of cases of chemotherapy-induced OM; recognizing this pattern may improve the effectiveness of treatment.
接受化疗的儿童可能因非糜烂性反流病（NERD）而出现吞咽困难。癌症患儿中与NERD吞咽困难相关的口腔黏膜炎（OM）最近被定义为COMEDY（咬牙、口腔黏膜炎、闭眼、吞咽困难）。本研究旨在确定化疗引起的OM中COMEDY模式的患病率。
回顾了42例因血液肿瘤疾病接受化疗并出现OM的儿童的病历。收集了以下数据：年龄、血液肿瘤疾病类型、吞咽困难的存在情况、口腔黏膜病变类型（即传统口腔黏膜炎或COMEDY模式）、口腔病变部位、耳鼻喉（ENT）对NERD间接体征的评估以及儿科神经精神病学（PNP）评估。
在42例与化疗相关的OM患儿中，6例（14.2%）表现出COMEDY模式。除了最初被归类为II级OM的口腔黏膜特征性临床表现外，这些儿童还患有与NERD相关的吞咽困难和PNP问题。
COMEDY模式可能在一些化疗引起的OM病例中出现；认识到这种模式可能会提高治疗效果。
