Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China.
NMPA Research Base of Regulatory Science for Medical Devices, Institute of Regulatory Science for Medical Devices, Huazhong University of Science and Technology, Wuhan, 430074, China.
Adv Healthc Mater. 2023 Jun;12(16):e2201242. doi: 10.1002/adhm.202201242. Epub 2022 Aug 26.
To repair systematically osteoporotic bone defects, it is important to make an effort to both diminish osteoporosis and enhance bone regeneration. Herein, a specifically monoporous microsphere (MPM) carrier encapsulating dosage-sensitive and short half-time parathyroid hormone (PTH) is constructed to tackle the issue. Compared with conventional microsphere carriers involving compact, porous, and mesoporous microspheres, the MPM is desirable to achieve precisely in situ delivery and to minimize topical accumulation. The findings show that the PTH loaded inside MPMs can be gradually released from the single hole of MPMs to improve the initial drug concentration. Also, the MPMs can self-shift with the daily movement of experimental animals to effectively reduce the topical aggregation of released drugs in vitro. In vivo evaluation further confirms that the implant of MPMs-PTH plays a dual role in stimulating the regenerative repair of the cranial defect and relieving osteoporosis in the whole body. Consequently, the current work develops a dynamically movable drug delivery system to achieve precisely in situ delivery, minimize topical accumulation, and systematically repair osteoporotic bone defects.
为了系统性修复骨质疏松性骨缺损，既要努力减少骨质疏松症，又要增强骨再生。在此，构建了一种专门的单孔微球（MPM）载体来封装剂量敏感且半衰期短的甲状旁腺激素（PTH），以解决这一问题。与传统的微球载体（包括致密、多孔和中孔微球）相比，MPM 有利于实现精确的原位给药，并最大限度地减少局部聚集。研究结果表明，负载在 MPM 内部的 PTH 可以从 MPM 的单个孔中逐渐释放出来，以提高初始药物浓度。此外，MPM 可以随着实验动物的日常运动而自动移位，从而有效地减少体外释放药物的局部聚集。体内评价进一步证实，MPM-PTH 植入物在刺激颅缺损的再生修复和缓解全身骨质疏松症方面发挥双重作用。因此，本工作开发了一种可动态移动的药物输送系统，以实现精确的原位给药，最大限度地减少局部聚集，并系统性修复骨质疏松性骨缺损。
