Department of Emergency Medicine, University of Saskatchewan, Saskatchewan, Saskatoon, Canada
Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
BMJ Open. 2022 Aug 10;12(8):e057852. doi: 10.1136/bmjopen-2021-057852.
To determine the diagnostic yield of screening patients for SARS-CoV-2 who were admitted with a diagnosis unrelated to COVID-19 and to identify risk factors for positive tests.
Cohort from the Canadian COVID-19 Emergency Department Rapid Response Network registry.
30 acute care hospitals across Canada.
Patients hospitalised for non-COVID-19-related diagnoses who were tested for SARS-CoV-2 between 1 March and 29 December 2020.
Positive nucleic acid amplification test for SARS-CoV-2.
Diagnostic yield.
We enrolled 15 690 consecutive eligible adults who were admitted to hospital without clinically suspected COVID-19. Among these patients, 122 tested positive for COVID-19, resulting in a diagnostic yield of 0.8% (95% CI 0.64% to 0.92%). Factors associated with a positive test included presence of fever, being a healthcare worker, having a positive household contact or institutional exposure, and living in an area with higher 7-day average incident COVID-19 cases.
Universal screening of hospitalised patients for COVID-19 across two pandemic waves had a low diagnostic yield and should be informed by individual-level risk assessment in addition to regional COVID-19 prevalence.
NCT04702945.
确定对因非 COVID-19 相关诊断而住院的患者进行 SARS-CoV-2 筛查的诊断收益，并确定阳性检测的危险因素。
来自加拿大 COVID-19 急诊部快速反应网络登记处的队列研究。
加拿大 30 家急性护理医院。
2020 年 3 月 1 日至 12 月 29 日期间因非 COVID-19 相关诊断住院且接受 SARS-CoV-2 检测的患者。
SARS-CoV-2 核酸扩增检测阳性。
诊断收益。
我们纳入了 15690 名连续符合条件的成年人，他们在没有临床疑似 COVID-19 的情况下住院。在这些患者中，有 122 例 COVID-19 检测呈阳性，诊断收益为 0.8%（95%CI 0.64%至 0.92%）。与阳性检测相关的因素包括发热、医护人员、有阳性家庭接触者或机构暴露史，以及居住在 COVID-19 7 天平均发病率较高的地区。
在两次大流行浪潮中对住院患者进行 COVID-19 普遍筛查的诊断收益较低，除了 COVID-19 流行率外，还应根据个体风险评估来确定。
NCT04702945。
