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通过支气管肺泡灌洗术提高克什米尔地区呼吸道疾病诊断水平:检查结果分析

Enhancing respiratory disease diagnosis by bronchoalveolar lavage in Kashmir: an audit of findings.

作者信息

Bhat Javeed Iqbal, Tramboo Zubair M, Shah Tajamul Hussain, Charoo Bashir Ahmad, Qazi Iqbal Ahmad

机构信息

Pediatrics, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, India

Pediatrics, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, India.

出版信息

Arch Dis Child. 2022 Dec;107(12):1079-1082. doi: 10.1136/archdischild-2022-323823. Epub 2022 Aug 10.

Abstract

OBJECTIVE

To study bronchoalveolar lavage (BAL) findings in various respiratory diseases in children in Kashmir India.

DESIGN

Prospective observational study.

SETTING

Paediatric department of the tertiary care hospital.

PATIENTS

Children of both genders from 1 month to 17 years of age INTERVENTION: All studied patients underwent flexible bronchoscopy and BAL.

OUTCOME MEASURE

To observe the BAL findings in various respiratory diseases in the studied population.

RESULTS

A total of 283 patients underwent BAL procedure. The positive BAL report was received in 131 (46%) patients. Out of these, 55 (42%) patients had positive BAL culture/ microscopy for different bacterial (50) and fungal species ( spp (3), Mucormycosis (1) and (1)). MTB was isolated in 25 (19%) patients. Twenty-three (17.5%) patients had bronchoalveolar lavage fluid (BALF) positive for pulmonary hydatidosis. Foamy macrophages were seen in 13 patients, significant eosinophilia in nine patients and hemosiderin-laden macrophages were seen in three patients.

CONCLUSION

We found BALF a very useful sample for the evaluation of many infective and non-infective respiratory diseases in our region, which otherwise lacks high end diagnostics. 46% of our patients had some abnormalities in the BAL specimen. It provided us with valuable information regarding organism profile and drug sensitivity in case of lung infection. BALF analysis was also found useful in the diagnosis of some non-infective pulmonary disorders like acute eosinophilic pneumonia, aspiration syndromes and bronchial asthma.

摘要

目的

研究印度克什米尔地区儿童各种呼吸道疾病的支气管肺泡灌洗(BAL)结果。

设计

前瞻性观察研究。

地点

三级护理医院的儿科。

患者

年龄在1个月至17岁的男女儿童。干预措施:所有研究患者均接受了纤维支气管镜检查和BAL。

观察指标

观察研究人群中各种呼吸道疾病的BAL结果。

结果

共有283例患者接受了BAL操作。131例(46%)患者获得了阳性BAL报告。其中,55例(42%)患者的BAL培养/镜检对不同细菌(50种)和真菌(3种)、毛霉菌病(1例)及其他(1例)呈阳性。25例(19%)患者分离出结核分枝杆菌。23例(17.5%)患者的支气管肺泡灌洗液(BALF)对肺包虫病呈阳性。13例患者可见泡沫状巨噬细胞,9例患者有明显嗜酸性粒细胞增多,3例患者可见含铁血黄素巨噬细胞。

结论

我们发现BALF是评估我们地区许多感染性和非感染性呼吸道疾病的非常有用样本,否则该地区缺乏高端诊断方法。我们46%的患者BAL标本存在一些异常。它为我们提供了肺部感染时有关病原体谱和药物敏感性的有价值信息。BALF分析在诊断一些非感染性肺部疾病如急性嗜酸性粒细胞性肺炎、吸入综合征和支气管哮喘方面也很有用。

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