评估肺癌伴胸腔积液患者血清和胸腔液中肿瘤 M2-丙酮酸激酶水平。
Evaluation of serum and pleural levels tumor M2-pyruvate kinase in lung cancer patients with pleural effusion.
机构信息
Department of Respiratory Medicine, Affiliated Nanjing Brain Hospital, Nanjing Medical University, 215 Guangzhou Road, Nanjing, 210029, Jiangsu, China.
Clinical Center of Nanjing Respiratory Diseases and Imaging, Nanjing, 210029, Jiangsu, China.
出版信息
BMC Pulm Med. 2022 Aug 10;22(1):307. doi: 10.1186/s12890-022-02103-x.
OBJECTIVE
To evaluate the diagnostic value of tumor M2-pyruvate kinase (TuM2-PK) and carcinoembryonic antigen (CEA) levels in both pleural effusion and serum in the differential diagnosis of benign and malignant pleural effusion.
METHODS
This prospective study was conducted among 80 patients with benign pleural effusion (BPE group) and 125 patients with malignant pleural effusion associated with lung cancer (MPE group). The levels of TuM2-PK and CEA were measured by using sandwich enzyme-linked immunosorbent assay and electrochemiluminescence. The receiver-operating characteristic curve (ROC) analysis was used to confirm the cutoff value to evaluate the diagnostic efficiency of TuM2-PK and CEA.
RESULTS
The TuM2-PK and CEA levels in pleural effusion and serum, and their ratio (P/S) were higher in MPE group than that in BPE group (P < 0.05). In pleural effusion and serum, the diagnostic efficiency of combined TuM2-PK and CEA for MPE was superior to either single detection.
CONCLUSIONS
The combined detection of TuM2-PK and CEA has a high sensitivity for diagnosis of MPE and might provide method for rapid and accurate diagnosis of patients.
目的
评估肿瘤 M2-丙酮酸激酶（TuM2-PK）和癌胚抗原（CEA）在胸腔积液和血清中的水平在良恶性胸腔积液鉴别诊断中的诊断价值。
方法
前瞻性研究纳入 80 例良性胸腔积液（BPE 组）和 125 例肺癌相关恶性胸腔积液（MPE 组）患者。采用夹心酶联免疫吸附试验和电化学发光法检测 TuM2-PK 和 CEA 水平。采用受试者工作特征曲线（ROC）分析确定截断值，以评估 TuM2-PK 和 CEA 的诊断效率。
结果
MPE 组胸腔积液和血清中的 TuM2-PK 和 CEA 水平及其比值（P/S）均高于 BPE 组（P<0.05）。在胸腔积液和血清中，联合检测 TuM2-PK 和 CEA 对 MPE 的诊断效率优于单项检测。
结论
联合检测 TuM2-PK 和 CEA 对 MPE 的诊断具有较高的灵敏度，可能为患者的快速准确诊断提供方法。
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