Galabert C, Jacquot J, Zahm J M, Puchelle E
Clin Chim Acta. 1987 Apr 30;164(2):139-49. doi: 10.1016/0009-8981(87)90065-9.
The lipid composition and rheological properties of expectorated airway secretions have been analyzed in 16 patients with cystic fibrosis (CF), separated into two groups according to whether their secretions were superinfected or not. The total lipid content was higher in the superinfected CF secretions. The content in cholesterol and GL1, GL3 and GL4 glycosphingolipid fractions were significantly higher in the superinfected in comparison to the non-superinfected group. The viscosity was two-fold higher in the CF superinfected group. A significant correlation (r = 0.72, p less than 0.01) was observed between the apparent viscosity and the total lipid content of CF secretions. Cholesterol, glycosphingolipids and sphingomyelin were the lipid components which were the most closely and positively correlated to the viscosity. On the opposite, phosphoglycerol was negatively correlated (r = -0.72, p less than 0.05) to the viscoelastic properties of CF airway secretions.
对16例囊性纤维化（CF）患者咳出的气道分泌物的脂质成分和流变学特性进行了分析，根据分泌物是否发生重叠感染将患者分为两组。重叠感染的CF分泌物中总脂质含量较高。与未重叠感染组相比，重叠感染组中胆固醇以及GL1、GL3和GL4糖鞘脂组分的含量显著更高。CF重叠感染组的粘度高出两倍。观察到CF分泌物的表观粘度与总脂质含量之间存在显著相关性（r = 0.72，p < 0.01）。胆固醇、糖鞘脂和鞘磷脂是与粘度最密切且呈正相关的脂质成分。相反，磷酸甘油与CF气道分泌物的粘弹性呈负相关（r = -0.72，p < 0.05）。
